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Home / Biochemicals / Small Molecules

Geldanamycin

SKU : BHB21300167

A Powerful Anticancer Antibiotic

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Alomone Labs

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Mfr.No.	G-500, G-500_0.1 mg, G-500_1 mg
Description	Geldanamycin (#G-500) is a highly pure, natural, and biologically active compound.
Molecular Formula	C29H40N2O9.
Synonyms	Natural
Background	Geldanamycin is a potent antitumor antibiotic1 active against more than 50 tumor cell lines.2 Hsp90 is a molecular chaperone that regulates the folding, assembly and conformational maturation of proteins. It has a key role in cell response to environmental stress and in maintaining the malignant phenotype of tumor cells.3Geldanamycin binds into the ATPase binding pocket in Hsp90,4,5 and induces the degradation of proteins required by this chaparone to induce conformational maturation. Hsp90 client proteins include transcription factors (mutated p53, HIF-1a, EF-2),6,7 tyrosine kinases (v-Src, Bcr-Abl, erbB2),8,9 serine-threonine kinases (Raf-1),10,11 and the nuclear receptor family (androgen, estrogen).12 Hsp90 client proteins play important roles in the regulation of the cell cycle, cell growth, apoptosis, and oncogenesis, geldanamycin inhibits the proliferation of cultured cancer cells and shows anticancer activity in experimental animals.The antitumor effects involve different mechanisms such as destabilization of mutant p53 protein (breast and prostate cell lines)13 cell cycle arrest,13 inhibition of c-Jun expression,14 destabilization of Raf-1, destruction of EF-2 kinase, and inhibition of telomerase activity.15 Recently, synergistic effects of Geldanamycin with cytotoxic drugs16,17 increased tumor cell sensitivity to radiation.18,19
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 1 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	30562-34-6
Molecular Weight	560.6
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	Geldanamycin is a potent antitumor antibiotic1 active against more than 50 tumor cell lines2. It binds to the ATPase binding pocket in Hsp903,4 and induces the degradation of proteins required by this chaperone.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 17-Demethoxy-17-(2-propenylamino) geldanamycin.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.

Product Manual	SDS

Reference	DeBoer, C. et al. (1970) J. Antibiot. (Tokyo) 23, 442. Ochel, H.J. et al. (2001) Cell Stress Chaperones 6, 105. Goetz, M.P. et al. (2003) Ann. Oncol. 14, 1169. Stebbins, C.E. et al. (1997) Cell 89, 239. Grenert, J.P. et al. (1997) J. Biol. Chem. 272, 23843. Yang, J. et al. (2001) Cancer Res. 61, 4010. Whitesell, L. et al. (1998) Mol. Cell Biol. 18, 1517. Mimnaugh, E.G. et al. (1996) J. Biol. Chem. 271, 22796. Schnur, R.C. et al. (1995) J. Med. Chem. 38, 3813. Schulte, T.W. et al. (1997) Biochem. Biophys. Res. Commun. 239, 655. Xu, W. et al. (2003) Cancer Res. 63, 7777. Segnitz, B. et al. (1997) J. Biol. Chem. 272, 18694. McIlwrath, A.J. et al. (1996) Cancer Chemother. Pharmacol. 37, 423. Vasilevskaya, I.A. et al. (1999) Cancer Res. 59, 3935. Villa, R. et al. (2003) Carcinogenesis 24, 851. Liao, Z.Y. et al. (2001) Yao Xue Xue Bao. 36, 569. Nguyen, D.M. et al. (2001) Ann. Thorac. Surg. 72, 371. Karimpour, S.E. et al. (2003) Int. J. Radiat. Oncol. Biol. Phys. 57, S298. Machida, H. et al. (2003) Int. J. Radiat. Biol. 79, 973. DeBoer, C. et al. (1970) J. Antibiot. (Tokyo) 23, 442. Ochel, H.J. et al. (2001) Cell Stress Chaperones 6, 105. Goetz, M.P. et al. (2003) Ann. Oncol. 14, 1169. Stebbins, C.E. et al. (1997) Cell 89, 239.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300167-1	G-500_0.1 mg	0.1 mg	$120		Add to Cart
BHB21300167-2	G-500_1 mg	1 mg	$506		Add to Cart
BHB21300167-3	G-500_0.1 mg	5x0.1 mg	$506		Add to Cart
BHB21300167-4	G-500_1 mg	5x1 mg	$2152		Add to Cart

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