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Home / Biochemicals / Small Molecules

Genistein

SKU : BHB21300166

A Tyrosine Kinase Inhibitor

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Alomone Labs

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Mfr.No.	G-300, G-300_10 mg, G-300_100 mg, G-300_25 mg
Description	Genistein (#G-300) is a highly pure, natural, and biologically active compound.
Molecular Formula	C15H10O5.
Background	An isoflavonoid derived from soy products,1 Genistein inhibits protein tyrosine kinases including the EGF receptor kinase (IC50 = 2.6 uM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor.1,2 It has a trivial effect on the activity of PKA and PKC (IC50 > 350 uM).1,2 In addition, Genistein inhibits Topoisomerase II activity,3 causes cell cycle arrest and apoptosis in Jurkat T-leukemia cells.4 It down regulates the transcription of genes involved in angiogenesis,5,6 and inhibits the action of GABA on recombinant GABA-A receptors.7 Genistein also inhibits tumor cell proliferation and induces tumor cell differentiation.8-10
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-10 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	446-72-0
Molecular Weight	270.2
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Source	Natural
Activity	Genistein, apart from a broad range of biological roles, is well established as a tyrosine kinase inhibitor1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Polkowski, K. and Mazurek, A.P. (2000) Acta Pol. Pharm. 57, 135. Sarkar, F.H. and Li, Y. (2002) Cancer Metastasis Rev. 21, 265. Salti, G.I. (2000) Eur. J. Cancer. 36, 796. Spinozzi, F. et al. (1994) Leuk. Res. 18, 431. Myoung, H. et al. (2003) Cancer Sci. 94, 215. Li, Y. and Sarkar, F.H. (2002) Cancer Lett. 186, 157. Huang, R.Q. et al. (1999) Brain Res. Mol. Brain Res. 67, 177. Constantinou, A. and Huberman, E. (1995) Proc. Soc. Exp. Biol. Med. 208, 109. Khoshyomn, S. et al. (2002) J. Neurooncol. 57, 193. Tamura, S. et al. (2003) Pigment Cell Res. 16, 470. Akiyama, T. et al. (1987) J. Biol. Chem. 262, 5592.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300166-1	G-300_10 mg	10 mg	$91		Add to Cart
BHB21300166-2	G-300_100 mg	100 mg	$351		Add to Cart
BHB21300166-3	G-300_25 mg	25 mg	$176		Add to Cart
BHB21300166-4	G-300_10 mg	5x10 mg	$331		Add to Cart
BHB21300166-5	G-300_25 mg	5x25 mg	$689		Add to Cart

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