JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Ginkgolide B

SKU : BHB21300155

An Antagonist of 5-HT3A Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	G-170, G-170_10 mg, G-170_25 mg, G-170_50 mg
Description	Ginkgolide B (#G-170) is a highly pure, natural, and biologically active compound.
Molecular Formula	C20H24O10.
Background	Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Ginkgolide B is a natural non-selective blocker of 5-HT3A channel. Ginkgolide is extracted from the leaves, roots and bark of the tree Ginkgo biloba. Ginkgolide B has an effective concentration of 500-1000 uM and an IC50 of 730 uM for the 5-HT3A receptor and an IC50 of 3.9 mM for the 5-HT3B receptor thus enabling discrimination between the two. Ginkgolide also binds to anion Cys-loop receptors such as GABA and glycine receptors. Ginkgolide does not displace the specific 5-HT3 receptor antagonist granisetron, thus confirming that it does not act at the agonist binding site. In addition, inhibition by Ginkgolide at 5-HT3A receptors is weakly use-dependent, and recovery of the receptor is also activity dependent, indicating channel block as the mechanism of inhibition. Ginkgolide is widely used in traditional medicine and has a wide spectrum of beneficial properties such as anti-convulsion, neuro-protection and reducing anxiety2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	500-1000 uM.
Reconstitution	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	15291-77-7
Molecular Weight	424.4
Solubility	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3A receptors
Source	Natural
Activity	Ginkgolide B is a 5-HT3A channel blocker1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: ((1R,3R,6R,7S,8S,10R,11R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo(8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17})nonadecane-5,15,18-trione.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hannon, J. et al. (2008) Behav. Brain Res. 195, 198. Tompson, A.J. et al. (2011) Neuropharmacology 60, 488. Tompson, A.J. et al. (2011) Neuropharmacology 60, 488.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300155-1	G-170_10 mg	10 mg	$50		Add to Cart
BHB21300155-2	G-170_25 mg	25 mg	$85		Add to Cart
BHB21300155-3	G-170_50 mg	50 mg	$151		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.