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Home / Biochemicals / Small Molecules

GMQ hydrochloride

SKU : BHB21300154

An ASIC Channel Modulator and an ASIC3 Channel Opener

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Alomone Labs

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Mfr.No.	G-165, G-165_10 mg, G-165_250 mg, G-165_5 mg, G-165_50 mg
Description	GMQ hydrochloride (#G-165) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H12ClN5.
Synonyms	Synthetic
Background	2-guanidine-4-methylquinazoline (GMQ) is a small synthetic nonproton molecule that activates ASIC channels (acid-sensing ion channels). ASICs are proton-gated ion channels which are activated by a decrease in extracellular pH. GMQ is an activator of ASIC3 channels under physiological pH conditions; it induces a window current at pH 7.4 only in ASIC3. Evidence shows that GMQ alters the pH dependence of all ASIC subtypes studied1,2.GMQ contains basic groups that seem to form tight contacts with the carboxyl groups of acidic residues through hydrogen bonds (H-bonds) and electrostatic interactions that lead to the activation of ASIC3. In addition, GMQ contains a guanidinium group and a heterocyclic ring.Additional studies showed that GMQ activates sensory neurons and causes pain-related behaviors in an ASIC3-dependent manner3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-5 mM.
Reconstitution	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	5361-15-9
Molecular Weight	237.1
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	ASIC1a, ASIC2, ASIC3
Activity	GMQ is an ASIC modulator, an ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -31.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(4-methylquinazolin-2-yl)guanidine hydrochloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Alijevic, O. and Kellenberger, S. (2012) J. Biol. Chem. 287, 36059. Li, W.G. et al. (2010) Mol. Pain 88, 1186. Li, W.G. et al. (2011) J. Biol. Chem. 286, 42635. Alijevic, O. and Kellenberger, S. (2012) J. Biol. Chem. 287, 36059.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300154-1	G-165_10 mg	10 mg	$66		Add to Cart
BHB21300154-2	G-165_250 mg	250 mg	$337		Add to Cart
BHB21300154-3	G-165_5 mg	5 mg	$50		Add to Cart
BHB21300154-4	G-165_50 mg	50 mg	$85		Add to Cart

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