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Home / Biochemicals / Small Molecules

GMQ

SKU : BHB21300150

An ASIC Channel Modulator and an ASIC3 Channel Opener

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Alomone Labs

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Mfr.No.	G-130, G-130_10 mg, G-130_25 mg, G-130_5 mg, G-130_50 mg
Description	GMQ (#G-130) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H11N5.
Synonyms	Synthetic
Background	2-guanidine-4-methylquinazoline (GMQ) is a small synthetic nonproton molecule that activates ASIC channels (acid-sensing ion channels). ASICs are proton-gated ion channels which are activated by a decrease in extracellular pH. GMQ is an activator of ASIC3 channels under physiological pH conditions; it induces a window current at pH 7.4 only in ASIC3. Evidence shows that GMQ alters the pH dependence of all ASIC subtypes studied1,2.GMQ contains basic groups that seem to form tight contacts with the carboxyl groups of acidic residues through hydrogen bonds (H-bonds) and electrostatic interactions that lead to the activation of ASIC3. In addition, GMQ contains a guanidinium group and a heterocyclic ring.Additional studies showed that GMQ activates sensory neurons and causes pain-related behaviors in an ASIC3-dependent manner3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-5 mM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	716-11-0
Molecular Weight	201.2
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	ASIC1a, ASIC2, ASIC3
Activity	GMQ is an ASIC modulator, ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -31.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(4-methylquinazolin-2-yl)guanidine.

Purity	0.99
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Alijevic, O. and Kellenberger, S. (2012) J. Biol. Chem. 287, 36059. Li, W.G. et al. (2010) Mol. Pain 88, 1186. Li, W.G. et al. (2011) J. Biol. Chem. 286, 42635. Alijevic, O. and Kellenberger, S. (2012) J. Biol. Chem. 287, 36059.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300150-1	G-130_10 mg	10 mg	$151		Add to Cart
BHB21300150-2	G-130_25 mg	25 mg	$306		Add to Cart
BHB21300150-3	G-130_5 mg	5 mg	$85		Add to Cart
BHB21300150-4	G-130_50 mg	50 mg	$544		Add to Cart

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