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Home / Biochemicals / Small Molecules

GW441756

SKU : BHB21300156

A Potent Inhibitor of TrkA

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Alomone Labs

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Mfr.No.	G-190, G-190_1 mg, G-190_10 mg, G-190_25 mg, G-190_5 mg, G-190_50 mg
Description	GW441756 (#G-190) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H13N3O.
Background	GW441756 is a potent and selective inhibitor of the NGF receptor tyrosine kinase A (TrkA). This compound also inhibits TrkB and TrkC but displays significantly higher selectivity for TrkA receptor than other TrkA inhibitors and a 100-fold selectivity over a range of other kinases. The IC50 value of GW441756 is 2 nM1,3.The compound induces a dose-dependent decrease in neoplastic proliferation and has the ability to increase levels of caspase-3 that can lead to apoptosis.Previous studies have shown that TrKA inhibitors have a relevant anti-proliferative effects in neoplasia compare to other TrkA inhibitors with a lower effective dosage1,3.Signaling through protein tyrosine kinase receptors is important for neuronal metabolism, promotion of neuronal survival, stimulating neurite growth, synaptogenesis and potentiating synaptic strength2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	2nM - 2 uM.
Reconstitution	4-10 mM in DMSO. Centrifuge all product preparations before use.
Cas Number	504433-23-2
Molecular Weight	275.3
Solubility	4-10 mM in DMSO. Centrifuge all product preparations before use.
Target	TrkA receptors
Source	Synthetic
Activity	GW441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (3Z)-3-((1-methylindol-3-yl)methylidene)-1H-pyrrolo(3,2-b)pyridin-2-one.

Purity	>=97% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Green, S.H . et al. (2012) Anat. Rec. 295, 1877. Wood, E.R. et al. (2004) Bioorg. Med. Chem. Lett. 14, 953. Wood, E.R. et al. (2004) Bioorg. Med. Chem. Lett. 14, 953.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300156-1	G-190_1 mg	1 mg	$31		Add to Cart
BHB21300156-2	G-190_10 mg	10 mg	$117		Add to Cart
BHB21300156-3	G-190_25 mg	25 mg	$263		Add to Cart
BHB21300156-4	G-190_5 mg	5 mg	$66		Add to Cart
BHB21300156-5	G-190_50 mg	50 mg	$476		Add to Cart

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