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Home / Biochemicals / Small Molecules

GYKI 52466 hydrochloride

SKU : BHB21300149

An Antagonist of AMPA and Kainate Receptors

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Alomone Labs

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Mfr.No.	G-125, G-125_10 mg, G-125_100 mg, G-125_25 mg, G-125_5 mg, G-125_50 mg
Description	GYKI 52466 hydrochloride (#G-125) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H16ClN3O2.
Background	GYKI 52466 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. It blocks GluK3 homomeric receptors with an IC50 of 63 uM and GluK2b(R)/GluK3 heteroreceptors with an IC50 of 32 uM at high concentrations. GYKI 52466 has been reported to prevent the excitotoxic action of high extracellular glutamate levels due to its potent non-competitive AMPA receptor antagonistic effect. It has been demonstrated histologically that GYKI 52466 has neuroprotective actions in experimental models of global and focal cerebral ischaemia. The compound was widely investigated in experimental seizure models, where it provided effective protection against convulsions evoked by chemical agents such as AMPA or kainate, electroshock and audiogenic stimulation1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	300 nM - 300 uM.
Reconstitution	30 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	192065-56-8
Molecular Weight	329.78
Solubility	30 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	AMPA/Kainate receptors
Source	Synthetic
Activity	GYKI 52466 is a selective allosteric AMPA/kainate receptor antagonist, with an IC50 of ~10 uM for AMPA induced currents in cultured superior colliculus neurons1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride.

Purity	>96.6%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Szabados, T. et al. (2001) Brain Res. Bull. 55, 387. Rammes, G. et al. (1996) Br. J. Pharmacol. 117, 1209.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300149-1	G-125_10 mg	10 mg	$151		Add to Cart
BHB21300149-2	G-125_100 mg	100 mg	$1139		Add to Cart
BHB21300149-3	G-125_25 mg	25 mg	$355		Add to Cart
BHB21300149-4	G-125_5 mg	5 mg	$117		Add to Cart
BHB21300149-5	G-125_50 mg	50 mg	$636		Add to Cart

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