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Home / Biochemicals / Small Molecules

Isopimaric Acid

SKU : BHB21300180

A Novel Opener of KCa1.1 Channels

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Alomone Labs

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Mfr.No.	I-370, I-370_1 mg, I-370_10 mg, I-370_25 mg, I-370_5 mg
Description	Isopimaric Acid (#I-370) is a highly pure, natural, and biologically active compound.
Molecular Formula	C20H30O2.
Synonyms	Natural
Background	Isopimaric acid (originally isolated from terpenoids) was found to be a potent opener of KCa1.1 (large conductance Ca2+-activated K+ (BK) channels. 1 uM Isopimaric acid doubled the current carried via KCa1.1 channels and this effect increased dose dependently. In analogy to the effects of pimaric acid, isopimaric acid may increase the open probability of single KCa1.1 channels by shifting both its voltage and Ca2+ dependence to more hyperpolarized voltages.1 KCa1.1 channels that were activated by isopimaric acid retain their charybdotoxin sensitivity.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
Cas Number	5835-26-7
Molecular Weight	302
Solubility	DMSO, ethanol, acetone or methanol. DMSO is suggested for biological experiments. DMSO solution should not exceed 0.03%. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa1.1 K+ channels
Activity	Isopimaric acid is a potent opener of large conductance Ca2+-activated K+ (BK) channels. 1 uM of Isopimaric acid doubles the current carried via BK channels. Isopimaric acid may increase the open probability by shifting the Ca2+ and voltage dependence to more hyperpolarized voltages1. The sensitivity is decreased in the Xenopus system compared to mammalian cells. BK channels activated by Isopimaric acid retain their charybdotoxin sensitivity.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-Phenanthrenecarboxylicacid,7-ethenyl- 1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahyde.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Imaizumi, Y. et al. (2002) Mol. Pharmacol. 62, 836. Imaizumi, Y. et al. (2002) Mol. Pharmacol. 62, 836.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300180-1	I-370_1 mg	1 mg	$75		Add to Cart
BHB21300180-2	I-370_10 mg	10 mg	$129		Add to Cart
BHB21300180-3	I-370_25 mg	25 mg	$261		Add to Cart
BHB21300180-4	I-370_5 mg	5 mg	$91		Add to Cart
BHB21300180-5	I-370_1 mg	5x1 mg	$282		Add to Cart

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