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Home / Biochemicals / Small Molecules

Kainic acid monohydrate

SKU : BHB21300193

A Selective Agonist of Kainate Receptors and a Partial Agonist of AMPA Receptors

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Mfr.No.	K-200, K-200_10 mg, K-200_25 mg, K-200_5 mg, K-200_50 mg
Description	Kainic acid monohydrate (#K-200) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H15NO4 · H2O
Synonyms	Synthetic
Background	Kainic acid is an analog of the excitotoxic neurotransmitter glutamate used as a selective agonist of Kainate receptors1,2.Studies show that treatment with Kainic acid may induce seizures leading to neuronal death and biochemical changes similar to those seen in human patients with temporal lobe epilepsy1. Kainic acid may induce apoptotic death of rat striatal neurons in an autophagic mechanism2. Several studies of rat model show progressive death of nigral neurons following unilateral injection of Kainic acid in the striatum3.Kainate-type glutamate receptors (KARs) are highly expressed in the developing brain, where they are tonically activated to modulate synaptic transmission, network excitability and synaptogenesis4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Soluble up to 25 mM in water. Gentle warming may be required. Spin down all products before handling.
Cas Number	58002-62-3
Molecular Weight	231.25
Solubility	Soluble up to 25 mM in water. Gentle warming may be required. Spin down all products before handling.
Target	Kainate receptors, AMPA receptors
Activity	Kainic acid, a cyclic analogue of glutamic acid, is a selective agonist of the kainate receptors (EC50 = 0.6 uM - 7.4 uM, depending on subtype) 1,2, and a partial agonist at AMPA receptors (EC50 = 31 uM - 170 uM, depending on subtype) 1,3. Kainic acid has neuro-excitotoxic and epileptogenic activity in vivo4,5.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid;hydrate.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Kim, S. et al. (2017) Exp. Neurobiol. 26, 266. Wang, Y. et al. (2008) Autophagy 4, 214. Foster, J.A. et al. (2003) J. Chem. Neuroanat. 26, 65. Orav, E. et al. (2017) eNeuro 4, e0048. Donevan, S.D. et al. (1998) J. Pharmacol. Exp. Ther. 285, 539. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. Armstrong, N. and Gouaux, E. (2000) Neuron 28, 165. Kim, S. et al. (2017) Exp. Neurobiol. 26, 266. Foster, J.A. et al. (2003) J. Chem. Neuroanat. 26, 65.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300193-1	K-200_10 mg	10 mg	$340		Add to Cart
BHB21300193-2	K-200_25 mg	25 mg	$706		Add to Cart
BHB21300193-3	K-200_5 mg	5 mg	$184		Add to Cart
BHB21300193-4	K-200_50 mg	50 mg	$1338		Add to Cart

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