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Home / Biochemicals / Small Molecules

KT5720

SKU : BHB21300192

A Selective PKA Inhibitor

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Alomone Labs

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Mfr.No.	K-190, K-190_0.1 mg, K-190_0.25 mg, K-190_0.5 mg, K-190_50 mcg
Description	KT5720 (#K-190) is a highly pure, semi-synthetic, and biologically active compound.
Molecular Formula	C32H31N3O5.
Background	KT5720 is a semi-synthetic derivative of K525a. It is a cell-permeable, selective inhibitor of cAMP-dependent protein kinase (PKA; IC50 = 56 nM). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK), was observed.1 KT5720 was used to examine the role of PKA in various cellular events such as cell adhesion,2 neurite branching,3 anterograde axonal transport,4 memory consolidation,5,6 and regulation of transcription by cyclic AMP-dependent response element-binding protein (CREB).7
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100-500 nM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	108068-98-0
Molecular Weight	537
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	PKA
Source	Semi-synthetic
Activity	KT5720 is a potent and specific inhibitor of PKA (IC50 = 56 nM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9- meth yl-1-oxo-9,12-epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)py rrolo(3,4- i)(1,6)benzodiazocine-10-carboxylic acid, hexyl ester.

Purity	>99% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Kase, H. et al. (1987) B.B.R.C. 142, 436. Mohri, T. et al. (1998) Cell. Struct. Funct. 23, 255. Audesirk, G. et al. (1997) Brain Res. Dev. Brain Res. 102, 247. Okada, Y. et al. (1995) J. Neurosci. 15, 3053. Vianna, M.R. et al. (1999) Behav. Pharmacol. 10, 223. Huang, Y.Y. et al. (2000) J. Neurosci. 20, 6317. Kim, M.S. et al. (2002) Biochem. Biophys. Res. Commun. 291, 663. Kase, H. et al. (1987) Biochem. Biopphys. Res. Commun. 142, 436.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300192-1	K-190_0.1 mg	0.1 mg	$170		Add to Cart
BHB21300192-2	K-190_0.25 mg	0.25 mg	$383		Add to Cart
BHB21300192-3	K-190_0.5 mg	0.5 mg	$707		Add to Cart
BHB21300192-4	K-190_50 mcg	50 mcg	$92		Add to Cart

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