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Home / Biochemicals / Small Molecules

L-651,582

SKU : BHB21300195

An Effective Blocker of L-Type CaV Channels

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Alomone Labs

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Mfr.No.	L-110, L-110_10 mg, L-110_25 mg, L-110_5 mg, L-110_50 mg
Description	L-651,582 (#L-110) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H12Cl3N5O2.
Synonyms	Synthetic
Background	Two subtypes of voltage-gated Ca2+ channels (VGCC, CaV) are found in most non-excitable cells, the T-type (CaV3) and the L-Type (CaV1) Ca2+ channels1-2.L-651,582 is an anti-proliferative, anti-angiogenic, anti-metastatic and anti-parasitic agent3-5, which is also selective towards numerous mismatch repair-deficient tumor cell lines in vitro.6 It is a voltage-gated L-type Ca2+ channel blocker with an IC50 of 0.5 ug/ml5 . Patch clamp measurements of current through L- and T-type channels in guinea pig atrial cells also indicate that L-651,582 is a Ca2+ antagonist5. Block of L-type Ca2+ channels is voltage-dependent and the apparent dissociation constant for the high affinity state is 0.2 ug/ml. The IC50 for block of T-type Ca2+ channels is 1.4 ug/ml5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-200 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	99519-84-3
Molecular Weight	424.7
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	L-type Ca2+ channels
Activity	L-651,582 inhibits CaV channels as well as receptor activated Ca2+ signals in guinea pig atrial cells1, thus it is an L-type, voltage-gated Ca2+ channel blocker with additional antiproliferative activities2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-Amino-1-((3,5-dichloro-4-(4-chlorobenzoyl)phenyl)methyl)-1H-1,2,3-triazole-4-carboxamide.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Schramm, M. et al. (1988) Calcium in drug actions (Baker, P. F., ed), 90-113. Narahashi, T. et al. (1988) Calcium in drug actions (Baker, P. F., ed), 255-174. Kohn, E.C. et al. (1990) J. Nat. Cancer Int. 82, 54. Felder, C.C. et al.(1991) J. Pharm. Exp. Ther. 257, 967. Hupe, D.J. et al. (1991) J. Biol. Chem. 266, 10136. Yang, J.L. et al. (2008) Int. J. Cancer 123, 258. Hupe, D.J. et al. (1991) J. Biol. Chem. 266, 10136. Guo, L. et al. (1991) Eur. J. Pharmacol. 538, 15.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300195-1	L-110_10 mg	10 mg	$167		Add to Cart
BHB21300195-2	L-110_25 mg	25 mg	$337		Add to Cart
BHB21300195-3	L-110_5 mg	5 mg	$91		Add to Cart
BHB21300195-4	L-110_50 mg	50 mg	$705		Add to Cart

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