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Home / Biochemicals / Small Molecules

L-Ascorbic acid

SKU : BHB21300198

A Blocker of T-Type CaV Channels

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Mfr.No.	L-140, L-140_10 g, L-140_100 g, L-140_25 g, L-140_50 g
Description	L-Ascorbic acid (#L-140) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C6H8O6.
Synonyms	Synthetic
Background	The T-type calcium channel belongs to the voltage-gated Ca2+ channel (CaV) family. "T" stands for transient, referring to the length of activation. As with other sub-types of voltage-gated Ca2+ channels, the alpha1 subunit is the one that determines most of the channel's properties. T-type calcium channels may contain one of three alpha1 subunits, alpha1G (CaV3.1), alpha1H (CaV3.2) or alpha1I (CaV3.3)1-3.T-type Ca2+ channels are involved in the control of neuronal excitability and their gating can be modulated by a variety of redox agents4.L-Ascorbic acid (ascorbate) is an endogenous redox agent that selectively inhibits native CaV3.2 channels in the peripheral and central neurons4.L-Ascorbic acid has an IC50 of 6.5 uM on T-type current of rat DRG neurons, and IC50s of 10 and 25 nM on cloned CaV3.2 channels from human and rat, respectively4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 5 uM.
Reconstitution	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	50-81-7
Molecular Weight	176.1
Solubility	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	T-type Ca2+ channels
Activity	IC50 of 6.5 uM on T-type current of rat DRG neurons1. IC50s of 10 and 25 nM on cloned CaV3.2 channels from human and rat, respectively1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-Oxo-L-gulofuranolactone.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Nilius, B. et al. (2006) Cell Calcium 40, 81. Perez-Reyes, E. and Lory, P. (2006) CNS Neurol. Disord. Drug Targets 5, 605. Talavera, K. and Nilius, B. (2006) Cell Calcium 40, 97. Nelson, M.T. et al. (2007) J. Neurosci. 27, 12577. Nelson, M.T. et al. (2007) J. Neurosci. 27, 12577.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300198-1	L-140_10 g	10 g	$37		Add to Cart
BHB21300198-2	L-140_100 g	100 g	$75		Add to Cart
BHB21300198-3	L-140_25 g	25 g	$45		Add to Cart
BHB21300198-4	L-140_50 g	50 g	$55		Add to Cart

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