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Home / Biochemicals / Small Molecules

L-Quisqualic acid

SKU : BHB21300207

An Agonist of AMPA Receptors

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Mfr.No.	L-210, L-210_1 mg, L-210_10 mg, L-210_25 mg, L-210_5 mg, L-210_50 mg
Description	L-Quisqualic acid (#L-210) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C5H7N3O5.
Synonyms	Synthetic
Background	Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions. AMPA-type glutamate receptors are tetrameric ion channels that mediate fast excitatory synaptic transmission in the mammalian brain.L-Quisqualic acid (Quisqualate) is a selective agonist of AMPA receptors. Quisqualate binds to the AMPA receptor subunit GluR2 at the base of a deep cleft between two globular domains (GluR2-S1S2) causing the translation and rotation of domain S2 so that the cleft closes. The rate in which quisqualate dissociates from the AMPA receptor is primarily determined by the rate at which the receptor's binding domain opens. Mutations that destabilize the closed-cleft conformation of the receptor increase the rate of quisqualate dissociation and alter its relative efficacy1. Interestingly, although glutamate is known to cause an increase in human melanoma cell viability quisqualate does not create a similar effect even though it stimulates PI hydrolysis, thus suggesting it is a "G-protein biased agonist"2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.01-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in water. Once dissolved in water, add an equal volume of glycerol. Do not shake or vortex. Avoid multiple freeze-thawing cycles
Cas Number	###############################################################################################################################################################################################################################################################
Molecular Weight	189.1
Solubility	20 mM in H2O. Centrifuge all product preparations before use (10 000 x g for 1 min).
Target	AMPA receptors
Activity	L-Quisqualic acid is a selective AMPA receptor agonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid.

Purity	0.98
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Zhang, W. et al. (2006) Biophys. J. 91, 1336. Gelb, T. et al. (2015) Biochem. Pharmacol. 98, 182. Zhang, W. et al. (2006) Biophys. J. 91, 1336.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300207-1	L-210_1 mg	1 mg	$85		Add to Cart
BHB21300207-2	L-210_10 mg	10 mg	$235		Add to Cart
BHB21300207-3	L-210_25 mg	25 mg	$561		Add to Cart
BHB21300207-4	L-210_5 mg	5 mg	$134		Add to Cart
BHB21300207-5	L-210_50 mg	50 mg	$969		Add to Cart

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