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Home / Biochemicals / Small Molecules

Lerisetron

SKU : BHB21300203

A Potent Antagonist of 5-HT3 Channels

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Alomone Labs

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Mfr.No.	L-175, L-175_10 mg, L-175_25 mg, L-175_5 mg, L-175_50 mg
Description	Lerisetron (#L-175) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H20N4.
Background	Lerisetron, a piperazinylbenzimidazole derivative, is a potent and highly selective blocker of serotonin 5-HT3 channels with antiemetic effects. The drug is shown to be effective in the treatment of nausea and vomiting caused by emetogenic cytotoxic drugs1,2.Lerisetron antagonizes the serotonin action on the presynaptic 5-HT3 receptor that is implicated at the emetic reflex2,3.The 5-HT3 receptor mediates the action of serotonin in the body. This receptor is a member of the Cys-loop ligand-gated cation channels, which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions such as: emotion, cognition, memory, pain perception, and gastrointestinal functions including secretion and motility4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-100 nM.
Reconstitution	100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	143257-98-1
Molecular Weight	292.4
Solubility	100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3A receptors
Source	Synthetic
Activity	Lerisetron inhibits the 5-HT-induced Bezold-Jarisch reflex in anesthetized rats, pKi = 9.21.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-benzyl-2-piperazin-1-ylbenzimidazole.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Gomez-de-Segura, I.A. et al. (1998) Acta. Oncol. 37, 759. Jauregizar, N. et al. (2002) J. Pharm. Sci. 91, 41. Ortega, F. et al. (2005) Pharm. Res. 22, 1769. Kato, S. (2013) Biol. Pharm. Bull. 36, 1406. Orjales, A. et al. (1997) J. Med. Chem. 40, 586.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300203-1	L-175_10 mg	10 mg	$254		Add to Cart
BHB21300203-2	L-175_25 mg	25 mg	$569		Add to Cart
BHB21300203-3	L-175_5 mg	5 mg	$151		Add to Cart
BHB21300203-4	L-175_50 mg	50 mg	$1019		Add to Cart

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