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Home / Biochemicals / Small Molecules

Ligustilide

SKU : BHB21300202

An Activator of TRPA1 Channels

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Alomone Labs

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Mfr.No.	L-170, L-170_10 mg, L-170_100 mg, L-170_25 mg, L-170_50 mg
Description	Ligustilide (#L-170) is a highly pure, natural, and biologically active compound.
Molecular Formula	C12H14O2.
Synonyms	Natural
Background	Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel, which is expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA11.Ligustilide is a natural agonist of TRPA1 channels produced from the Umbelliferae plant Angelica sinensis with an effective concentration of 10-200 uM and an EC50 of 44 uM when binding to TRPA1. Ligustilide has a significant neuroprotective effect in transient forebrain ischemia and permanent cerebral focal ischemia. In a rat assay demonstrating ischemic damage, Ligustilide shortened mean escape time compared to the control group and prevented the effects caused by ligation of both common carotids. Ligustilide also increases choline acetyltransferase activity in ischemic brain tissues and might have therapeutic potential in the treatment of vascular-cerebral pathologies2. Ligustilide also plays a role in the prevention of cell autophagy. In C2C12 cells, ligustilide causes a decrease in the production TNF-alpha induced autophagosomes3. Interestingly, Ligustilide can be found in various drugs used in traditional Chinese medicine such as Danzhi Xiaoyao San. This substance ameliorates depressive behavior via upregulation of serotonin production thus making Ligustilide a research candidate for psychological disorders4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-200 uM.
Reconstitution	Up 100 mM in DMSO and 50 mM in Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	4431-01-0
Molecular Weight	190.2
Solubility	Up 100 mM in DMSO and 50 mM in Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPA1 channels
Activity	Ligustilide activates TRPA1 with an EC50 of 44 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (3Z)-3-butylidene-4,5-dihydro-2-benzofuran-1-one.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Cvetkov, T.L. et al. (2011) J. Biol. Chem. 286, 38168. Kuang, X. et al. (2008) Pharmacol. Biochem. Behav. 88, 213. Zhong, J. et al. (2011) Pfulgers Arch. 462, 841. Zhu, X. et al. (2015) J. Ethnopharmacol. 3, 86. Zhong, J. et al. (2011) Pfulgers Arch. 462, 841.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300202-1	L-170_10 mg	10 mg	$66		Add to Cart
BHB21300202-2	L-170_100 mg	100 mg	$323		Add to Cart
BHB21300202-3	L-170_25 mg	25 mg	$117		Add to Cart
BHB21300202-4	L-170_50 mg	50 mg	$219		Add to Cart

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