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Home / Biochemicals / Small Molecules

LY 294002

SKU : BHB21300212

A Specific Inhibitor of PI3-Kinase

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Alomone Labs

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Mfr.No.	L-300, L-300_1 mg, L-300_5 mg
Description	LY 294002 (#L-300) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H17NO3.
Background	PI 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor and non-receptor tyrosine kinases.1,2 LY-294002 is a potent and specific cell-permeable inhibitor of Pl 3-kinase that acts on the ATP-binding site of the enzyme.3In in vitro assays it displays an IC50 of 1.4 uM on purified PI 3-kinase, but did not inhibit PKC, PKA, MAP kinase and PI 4-kinase.3 In fMet-Leu-Phe stimulated neutrophils, LY-294002 completely abolished PI 3-kinase activity at 50 uM.4 LY-294002 induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway.5,6 Thus LY-294002 is useful tool for identifying the biochemical events regulated by the PI3-K/Akt pathway.7 This pathway has important relevance to the cellular events involved in cancer.6,8,9
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	5-10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
Cas Number	154447-36-6
Molecular Weight	307.35
Solubility	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	PI3-Kinase
Source	Synthetic
Activity	LY 294002 is a potent and specific cell-permeable inhibitor of Pl3-kinase1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kapeller, R. et al. (1994) Bioessays 16, 565. Duronio, V. et al. (1998) Cell Signal. 10, 233. Vlahos, C.J. et al. (1994) J. Biol. Chem. 269, 5241. Vlahos, C.J. et al. (1995) J. Immunol. 154, 2413. Curnock, A.P. et al. (1998) Cell. Immunol. 187, 77. Nicholson, K.M. et al. (2003) Cancer Lett. 190, 31. Coffer, P.J. et al. (1998) Biochem. J. 335 (Pt 1), 1. Shao, J. et al. (2004) Cancer Res. 64, 229. Vivanco, I. et al. (2002) Nat. Rev. Cancer 2, 489. Vlahos, C.J. et al. (1994) J. Biol. Chem. 269, 5241.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300212-1	L-300_1 mg	1 mg	$75		Add to Cart
BHB21300212-2	L-300_5 mg	5 mg	$223		Add to Cart

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