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Home / Biochemicals / Small Molecules

MDL 72222

SKU : BHB21300215

An Antagonist of 5-HT3 Receptors

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Mfr.No.	M-155, M-155_10 mg, M-155_25 mg, M-155_50 mg
Description	MDL 72222 (#M-155) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H17Cl2NO2.
Synonyms	Synthetic
Background	Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.MDL 72222 (Bemesetron) is a synthetic, potent and selective antagonist of the 5-HT3 receptor. MDL 72222 has an effective concentration of 1 nM - 1uM and an ED50 of 9.27 nM. MDL 72222 produces blockade of the Bezold-Jarisch effect of 5-HT in anaesthetized rats. Inhibition of the 5-HT receptor by MDL 72222 is selective since high doses of MDL 72222 fail to alter response to electrical stimulation of efferent vagus nerves. In contrast, MDL 72222 proves only a weak and essentially non-selective antagonist of responses mediated by the 5-HT M-receptor present on the cholinergic nerves of guinea-pig ileum. MDL 72222 does not block smooth muscle contractile responses elicited by oxytocin or mediated through 5-HT D-receptors2. In addition, MDL 72222 also significantly reduces pancreatic enzyme secretion induced by luminal administration of L-trp or melatonin and reverses the effects of 5-HT on amylase secretion3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1uM.
Reconstitution	25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	40796-97-2
Molecular Weight	314.2
Solubility	25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3 receptor
Activity	MDL 72222 is an antagonist of 5-HT3 receptors1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (8-methyl-8-azabicyclo(3.2.1)octan-3-yl) 3,5-dichlorobenzoate.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hannon, J. et al. (2008) Behav. Brain Res. 195, 198. Fozard, J.R. (1984) Naunyn Schmiedebergs Arch. Pharmacol. 326, 36. Nawrot-Porabka, K. et al. (2013) Pharmacol. Rep. 65, 494. Fozard, J.R. (1984) Naunyn Schmiedebergs Arch. Pharmacol. 326, 36.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300215-1	M-155_10 mg	10 mg	$66		Add to Cart
BHB21300215-2	M-155_25 mg	25 mg	$85		Add to Cart
BHB21300215-3	M-155_50 mg	50 mg	$117		Add to Cart

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