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Home / Biochemicals / Small Molecules

ML133 hydrochloride

SKU : BHB21300226

A Selective Blocker of Kir2 Channels

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Mfr.No.	M-275, M-275_10 mg, M-275_100 mg, M-275_25 mg, M-275_5 mg, M-275_50 mg
Description	ML133 hydrochloride (#M-275) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H19NO · HCl.
Synonyms	Synthetic
Background	ML133 hydrochloride is a selective small molecule that acts as an inhibitor of Kir2 inward rectifier potassium channels. The compound blocks Kir2.1, Kir2.6, Kir2.2 and Kir2.3 and shows little or no effect on other Kir channels1. ML133 hydrochloride demonstrates IC50 values of 1.8, 2.8, 2.9 and 4.0 uM for Kir2.1, Kir2.6, Kir2.2 and Kir2.3, respectively at pH 7.41.Kir channels are a family of membrane proteins that selectively control the permeation of K+ ions across cell membranes. These channels play an important role in establishing the resting membrane potential of excitable cells, regulating pacing in cardiomyocytes and neurons, regulating pancreatic insulin secretion and renal K+ transport2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-20 uM.
Reconstitution	Soluble to 100 mM in DMSO. Spin down all products before handling.
Cas Number	1222781-70-5
Molecular Weight	313.82
Solubility	Soluble to 100 mM in DMSO. Spin down all products before handling.
Target	Kir2 channels
Activity	ML133 hydrochloride selectively inhibits Kir2 inward-rectifier potassium channels with IC50 values of 1.8, 2.8, 2.9 and 4.0 uM for Kir2.1, Kir2.6, Kir2.2 and Kir2.3, respectively (at pH 7.4), and with little or no effect on Kir4.1, Kir7.1 or Kir1.1 channels.1
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(4-methoxyphenyl)-~{N}-(naphthalen-1-ylmethyl)methanamine; hydrochloride.

Purity	>97%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C for several months. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Wang, H.R. et al. (2011) ACS Chem. Biol. 6, 845. Fürst, O. et al. (2014) Front. Physiol. 4, 404.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300226-1	M-275_10 mg	10 mg	$85		Add to Cart
BHB21300226-2	M-275_100 mg	100 mg	$527		Add to Cart
BHB21300226-3	M-275_25 mg	25 mg	$168		Add to Cart
BHB21300226-4	M-275_5 mg	5 mg	$66		Add to Cart
BHB21300226-5	M-275_50 mg	50 mg	$287		Add to Cart

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