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Home / Biochemicals / Small Molecules

NaV1.7-Compound 36

SKU : BHB21300111

A Potent and Selective Blocker of NaV1.7 Channels

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Alomone Labs

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Mfr.No.	CMN-003, CMN-003_10 mg, CMN-003_25 mg, CMN-003_5 mg, CMN-003_50 mg
Description	NaV1.7-Compound 36 (#CMN-003) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C20H14ClF3N2O5S.
Synonyms	Synthetic
Background	NaV1.7-Compound 36 is a potent and selective blocker of NaV1.7 channels. NaV1.7-Compound 36 inhibits human NaV1.7 channels with IC50 value of 69 nM1.There are nine mammalian subtypes of NaV channels: NaV1.1-NaV1.9. They are essential for the initiation of action potentials in excitable cells and are considered to be important therapeutic targets for numerous pathophysiological conditions such as cardiac arrhythmia, and epilepsy. NaV1.7 channel plays an important role in nociception and it is an important therapeutic target in chronic pain1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50 nM - 50 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	1694633-51-6
Molecular Weight	486.85
Solubility	Soluble up to 200 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	NaV1.7 channels
Activity	NaV1.7-Compound 36 is a potent and selective blocker of NaV1.7 channels. It inhibits human NaV1.7 with IC50 of 69 nM. Compound 36 is selective for NaV1.7 over other human NaV isoforms and important targets, such as hERG1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(5-Chloro-6-(2,5-difluorophenoxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide.

Purity	>99% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	DiMauro, E.F. et al. (2016) J. Med. Chem. 59, 7818. Klint J.K. et al. (2015) Br. J. Pharmacol. 172, 2445.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300111-1	CMN-003_10 mg	10 mg	$459		Add to Cart
BHB21300111-2	CMN-003_25 mg	25 mg	$912		Add to Cart
BHB21300111-3	CMN-003_5 mg	5 mg	$287		Add to Cart
BHB21300111-4	CMN-003_50 mg	50 mg	$1582		Add to Cart

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