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Home / Biochemicals / Small Molecules

NAX-5055

SKU : BHB21300249

An Agonist of GalR1 and GalR2 Galanin Receptors

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Mfr.No.	N-360, N-360_10 mg, N-360_25 mg, N-360_5 mg, N-360_50 mg
Description	NAX-5055 (#N-360) is a highly pure, synthetic, and biologically active modified peptide.
Molecular Formula	C104H174N24O22.
Background	NAX-5055 is an active analog of the endogenous neuropeptide galanin that acts as a galanin receptor 1 (GalR1) and galanin receptor 2 (GalR2) agonist. NAX-5055 demonstrates high affinity for the receptors and was shown to prevent seizures in mouse model of epilepsy following intraperitoneal administration1.NAX-5055 is a systemically-active, metabolically stable galanin analog that can penetrate the blood-brain-barrier and displays a potent anticonvulsant activity2,3.Galanin is widely expressed throughout the central and peripheral nervous systems. Galanin receptors belong to the family of G-protein coupled receptors. Studies show that galanin and its receptors are involved in the transmission and modulation of nociception in the central nervous system, at spinal cord levels and in the brain4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Sequence	(Sar)WTLNSAGYLLGPKKK(pal)K-NH2.
Concentration	1-100 nM.
Molecular Weight	2112.6 Da
Modifications	N-terminal glycine is substituted with sarcosine. Lys at position 16 is palmitoylated. C-terminal amidation.
Solubility	Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	Galanin Receptors
Activity	NAX-5055, a systemically active analogue of the endogenous neuropeptide galanin, is a high affinity galanin receptors ligand (Ki=3.5 nM and 51.5 nM for GalR1 and GalR2, respectively), shown to prevent seizures in mouse epilepsy model in vivo1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes

Purity	>98% (HPLC)
Form	Lyophilized powder.
Storage	Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Bulaj, G. et al. (2008) J. Med. Chem. 51, 8038. White, H.S. et al. (2009) Neurotherapeutics 6, 372. Flynn, S.P. and White, H.S. (2015) Neuropeptides 50, 35. Zhang, M.L. et al. (2017) Sci. Rep. 7, 45930. Bulaj, G. et al. (2008) J. Med. Chem. 51, 8038. White, H.S. et al. (2009) Neurotherapeutics 6, 372.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300249-1	N-360_10 mg	10 mg	$406		Add to Cart
BHB21300249-2	N-360_25 mg	25 mg	$747		Add to Cart
BHB21300249-3	N-360_5 mg	5 mg	$235		Add to Cart
BHB21300249-4	N-360_50 mg	50 mg	$1153		Add to Cart

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