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Home / Biochemicals / Small Molecules

NBQX disodium salt

SKU : BHB21300235

An Antagonist of AMPA/Kainate Receptors

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Mfr.No.	N-186, N-186_1 mg, N-186_10 mg, N-186_100 mg, N-186_25 mg, N-186_5 mg, N-186_50 mg
Description	NBQX disodium salt (#N-186) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C12H6N4Na2O6S.
Background	The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) is a non-N-methyl-D-aspartate (non-NMDA) type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS)1. AMPA receptors normally assemble from four genetically distinct subunits: GluR1, GluR2, GluR3, and GluR4, which combine to form receptor complexes with different functional properties2.NBQX (2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F) quinoxaline) is an analogue of the quinoxalinedione antagonists to the non-NMDA glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine site3. It is a specific and potent AMPA receptor antagonist and has been found to be neuroprotective in various models of ischemia and to have anticonvulsant properties in different models of epilepsy4. NBQX has been reported to block the excitatory actions of AMPA in rat neocortex slices while having no effect on NMDA responses5. It was also reported to selectively block AMPA-induced depolarizations but not spontaneous epileptiform discharges in Mg2+ free medium in the rat cortical wedge6. NBQX blocks AMPA and kainate receptors at micromolar concentrations7,8.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1- 500 uM.
Reconstitution	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	479347-86-9
Molecular Weight	380.2
Solubility	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	AMPA/Kainate receptors
Source	Synthetic
Activity	NBQX is a potent inhibitor of non-NMDA glutamate receptor channels exhibiting IC50s of 0.1-0.4 uM for AMPA and 1.7-8 uM for kainate receptors1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo(f)quinoxaline-7-sulfonamide disodium salt.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Joshi, P.P. et al. (2012) Int. J. Pharmacy Pharmaceutical Sci. 4, 45. Hollmann, M. and Heinemann, S. (1994) Annu. Rev. Neurosci. 17, 31. Goldstein, J.M. and Litwin, L.C. (1993) Mol. Chem. Neuropathol. 18, 145. Filliat, P. et al. (1998) Pharmacol. Biochem. Behavior 59, 1087. Sheardown M.J. et al. (1990) Science 247, 571. Robichaud L.J. et al. (1991) Neurosci. Abst. 17, 1168. Dzubay, J.A. and Jahr, C.E. (1999) J. Neurosci. 19, 5265. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300235-1	N-186_1 mg	1 mg	$37		Add to Cart
BHB21300235-2	N-186_10 mg	10 mg	$132		Add to Cart
BHB21300235-3	N-186_100 mg	100 mg	$959		Add to Cart
BHB21300235-4	N-186_25 mg	25 mg	$296		Add to Cart
BHB21300235-5	N-186_5 mg	5 mg	$76		Add to Cart
BHB21300235-6	N-186_50 mg	50 mg	$537		Add to Cart

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