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Home / Biochemicals / Small Molecules

NNC 55-0396 dihydrochloride

SKU : BHB21300239

A Blocker of T-type CaV Channels

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Mfr.No.	N-205, N-205_10 mg, N-205_25 mg, N-205_5 mg, N-205_50 mg
Description	NNC 55-0396 dihydrochloride (#N-205) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C30H39.8Cl1.8FN3O2.
Background	NNC 55-0396 dihydrochloride, is a structural analog of mibefradil (Ro 40-5967) that inhibits both T-type and high-voltage-activated (HVA) Ca2+ channels with a higher selectivity for T-type Ca2+ channels. NNC 55-0396 exerts no effect against high voltage Ca2+ channels at 100 uM, but inhibits T-type channels in HEK293 cells with a potency comparable to that of mibefradil (IC50 values of 6.8 versus 10.1 uM)1. NNC 55- 0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may function by dissolving in or passing through the plasma membrane of cells2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	50 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	357400-13-6
Molecular Weight	564.57
Solubility	50 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	T-type CaV channels
Source	Synthetic
Activity	NNC 55-0396 displays IC50 values of 6.8 and >100 uM for inhibition of CaV3.1 T-type channels and HVA currents respectively in INS-1 cells1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1S,2S)-2-(2-((3-(1H-Benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Huang, L. et al. (2004) J. Pharmacol. Exp. Ther. 309, 193. Chen, W.K. et al. (2010) J. Neurosci. 30, 10360. Huang, L. et al. (2004) J. Pharmacol. Exp. Ther. 309, 193.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300239-1	N-205_10 mg	10 mg	$286		Add to Cart
BHB21300239-2	N-205_25 mg	25 mg	$642		Add to Cart
BHB21300239-3	N-205_5 mg	5 mg	$229		Add to Cart
BHB21300239-4	N-205_50 mg	50 mg	$921		Add to Cart

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