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Home / Biochemicals / Small Molecules

Nonivamide

SKU : BHB21300242

A Potent Activator of TRPV1 Channels

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Alomone Labs

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Mfr.No.	N-220, N-220_1 g, N-220_250 mg, N-220_500 mg
Description	Nonivamide (#N-220) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H27NO4.
Synonyms	Synthetic
Background	Nonivamide is a synthetic analog of capsaicin, a pungent ingredient in chili peppers. It binds to TRPV1 channel and activates it with high potency (EC50 ? 10-7 M). Treatment with nonivamide activates TRPV1 channels, allowing non-selective cation flux into neurons, causing membrane depolarization and increase in cytosolic Ca2+ due to release of Ca2+ from the endoplasmic reticulum1.TRPV1 is a member of the TRP family of ion-channels and found throughout the body in epithelial cells and in peripheral and central terminals in neurons. The TRPV family includes six mammalian ion channels, TRPV1-TRPV6. TRPV1 is a Ca2+-permeable channel which is activated and modulated by a variety of exogenous stimuli such as heat, changes in pH, and irritant and pungent compounds and by selected molecules released during inflammatory processes and tissue damage2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 10 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	2444-46-4
Molecular Weight	293.4
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1 channels
Activity	Nonivamide is a TRPV1 activator1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-((4-hydroxy-3-methoxyphenyl)methyl)nonanamide.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Zhao, J. et al. (2006) Biochemistry 45, 4915. Ryskamp, D.A. et al. (2014) Cells 12, 9141. Thomas, K.C. et al. (2011) J. Pharmacol. Exp. Ther. 337, 400.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300242-1	N-220_1 g	1 g	$85		Add to Cart
BHB21300242-2	N-220_250 mg	250 mg	$50		Add to Cart
BHB21300242-3	N-220_500 mg	500 mg	$66		Add to Cart

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