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Home / Biochemicals / Small Molecules

Ononetin

SKU : BHB21300253

A Potent TRPM3 Channel Blocker and a TRPA1 Channel Activator

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Alomone Labs

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Mfr.No.	O-135, O-135_100 mg, O-135_250 mg, O-135_50 mg
Description	Ononetin (#O-135) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H14O4.
Background	Ononetin is a deoxybenzoin that acts as a potent TRPM3 channel blocker with an IC50 of 0.3 uM and a TRPA1 channel activator between 10-100 uM. The compound binds at an extracellularly accessible binding site of the channel1.TRPM3, the third member of the melastatin-related TRPM channel subfamily, is a Ca2+-permeable non-selective cation channel expressed highly in the brain, spinal cord, sensory neurons, pituitary, kidney, eye, testis and adipose tissue. TRPM3 acts as a volume-regulated ion channel involved in the modulation of insulin release in pancreatic islets2.TRPA1, transient receptor potential ankyrin 1, is a non-selective cation channel expressed in the small neurons of the dorsal root and trigeminal ganglia. It plays an important role in models of inflammatory and neuropathic pain and have the ability to detect pungent or irritant compounds3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
Cas Number	487-49-0
Molecular Weight	258.27
Solubility	Soluble in DMSO and ethanol.Centrifuge all products before use (10000 x g 5 min).
Target	TRPM3, TRPA1 channels
Source	Synthetic
Activity	Ononetin is a deoxybenzoin, a potent blocker of TRPM3 channels (IC50 = 0.3 uM), also shown to activate TRPA1 channels at 10-100 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Straub, I. et al. (2013) Br. J. Pharmacol. 168, 1835. Held, K. et al. (2015) Temperature 2, 201. Klionsky, L. et al. (2007) Mol. Pain 3, 39. Straub, I. et al. (2013) Br. J. Pharmacol. 168, 1835.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300253-1	O-135_100 mg	100 mg	$117		Add to Cart
BHB21300253-2	O-135_250 mg	250 mg	$254		Add to Cart
BHB21300253-3	O-135_50 mg	50 mg	$66		Add to Cart

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