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Home / Biochemicals / Small Molecules

PD 123319 ditrifluoroacetate

SKU : BHB21300270

A Potent and Selective Antagonist of Angiotensin II Receptor Type-2

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Mfr.No.	P-245, P-245_10 mg, P-245_25 mg, P-245_5 mg, P-245_50 mg
Description	PD 123319 ditrifluoroacetate (#P-245) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C35H34F6N4O7.
Synonyms	Synthetic
Background	PD 123319 ditrifluoroacetate is a potent and selective antagonist of Angiotensin II type 2 receptor (AT2R) with an IC50 value of 34 nM3. It is also a weak Angiotensin II type 1 receptor antagonist. PD 123319 blocks the activation of the receptor by angiotensin II (Ang II), a natural hormone produced in order to maintain normal regulation of the cardiovascular function1.Blocking the angiotensin system has an important role in preventing progressive renal dysfunction and cardiovascular morbidity and mortality by reducing blood pressure and proteinuria. Ang II receptor antagonists are useful tools for treatment of chronic kidney disease in diabetic and non-diabetic patients2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	136676-91-0
Molecular Weight	736.66
Solubility	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	AT2R receptors
Activity	An Angiotensin II Type 2 Receptor Antagonist1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (6S)-1-((4-(dimethylamino)-3-methylphenyl)methyl)-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo(4,5-c)pyridine-6-carboxylic acid;2,2,2-trifluoroacetic acid.

Purity	>=97%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Brasch, H. et al. (1993) Hypertension 22, 699. An, J.N. et al. (2015) PLoS One 10, e0128632. Blankley, C.J. et al. (1991) J. Med. Chem. 34, 3248. Blankley, C.J. et al. (1991) J. Med. Chem. 34, 3248.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300270-1	P-245_10 mg	10 mg	$192		Add to Cart
BHB21300270-2	P-245_25 mg	25 mg	$375		Add to Cart
BHB21300270-3	P-245_5 mg	5 mg	$132		Add to Cart
BHB21300270-4	P-245_50 mg	50 mg	$670		Add to Cart

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