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Home / Biochemicals / Small Molecules

PF-05186462

SKU : BHB21300288

A Potent and Selective Blocker of NaV1.7 Channels

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Alomone Labs

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Mfr.No.	P-365, P-365_10 mg, P-365_25 mg, P-365_5 mg, P-365_50 mg
Description	PF-05186462 (#P-365) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H10ClF4N5O3S2.
Background	PF-05186462 is a potent and selective NaV1.7 channel blocker displaying IC50 values of 21 nM for human NaV1.71.There are nine mammalian NaV channel subtypes: NaV1.1-NaV1.9. These channels are essential for action potential initiation and upstroke in excitable cells and are considered to be important therapeutic targets for numerous pathophysiological conditions such as cardiac arrhythmia, and epilepsy1,2.NaV1.7 channel plays an important role in the human pain signaling pathway and it is an important therapeutic target for treatment of chronic pain1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	20 nM - 5 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	1235406-03-7
Molecular Weight	531.89
Solubility	Soluble up to 200 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	NaV1.7 channels
Source	Synthetic
Activity	PF-05186462 is a potent and selective blocker of NaV1.7 channels, shown to inhibit human NaV1.7 channels with IC50 of 21 nM, and tested for clinical application in human microdose studies1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide.

Purity	>96% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Jones, H.M. et al. (2016) Clin. Pharmacokinet. 55, 875. Klint, J.K. et al. (2015) Br. J. Pharmacol. 172, 2445.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300288-1	P-365_10 mg	10 mg	$638		Add to Cart
BHB21300288-2	P-365_25 mg	25 mg	$1114		Add to Cart
BHB21300288-3	P-365_5 mg	5 mg	$459		Add to Cart
BHB21300288-4	P-365_50 mg	50 mg	$1564		Add to Cart

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