JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

PF-05241328

SKU : BHB21300284

A Potent and Selective Blocker of NaV1.7 Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	P-345, P-345_10 mg, P-345_25 mg, P-345_5 mg, P-345_50 mg
Description	PF-05241328 (#P-345) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H21ClN4O4S.
Background	PF-05241328 a potent and selective blocker of NaV1.7 channels with IC50 value of 31 nM1. PF-05089771 is being used to explore the NaV1.7 channel blockade for the treatment of acute or chronic pain conditions1,2.NaV1.7 channel plays an important role in the human pain signaling pathway and it is an important therapeutic target for treatment of chronic pain.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50 nM - 50 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	1387633-03-5
Molecular Weight	436.91
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	NaV1.7 channels
Source	Synthetic
Activity	PF-05241328 is a potent and selective blocker of NaV1.7 channels, shown to inhibit human NaV1.7 channels with IC50 of 31 nM, and tested for clinical application in human microdose studies1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(5-chloro-6-(2-methylpropoxy)pyridin-3-yl)-3-methyl-N-methylsulfonylindazole-5-carboxamide.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Jones, H.M. et al. (2016) Clin. Pharmacokinet. 55, 875. Klint, J.K. et al. (2015) Br. J. Pharmacol. 172, 2445.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300284-1	P-345_10 mg	10 mg	$459		Add to Cart
BHB21300284-2	P-345_25 mg	25 mg	$798		Add to Cart
BHB21300284-3	P-345_5 mg	5 mg	$287		Add to Cart
BHB21300284-4	P-345_50 mg	50 mg	$1275		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.