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Home / Biochemicals / Small Molecules

PF-06439015

SKU : BHB21300286

A Potent Inhibitor of TrkA/B and other Receptor Tyrosine Kinases

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Alomone Labs

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Mfr.No.	P-355, P-355_10 mg, P-355_25 mg, P-355_5 mg, P-355_50 mg
Description	PF-06439015 (#P-355) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C22H23FN6O3S.
Background	PF-06439015 is a synthetic compound that acts as a potent inhibitor of receptor tyrosine kinases. It inhibits various tyrosine kinases including ALK, ROS1, FER, LTK and TrkB with IC50 values of less than 10 nM1.Tyrosine kinases are a family of enzymes that acts as important mediators of the signaling cascade leading to cell proliferation, differentiation, migration, metabolism, and programmed cell death. Tyrosine kinases catalyze phosphorylation of select tyrosine residues in target proteins2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	1549629-82-4
Molecular Weight	470.52
Solubility	Soluble in DMSO. Centrifuge before reconstitution (10000 x g 5 min).
Target	ALK, ROS1, FER, LTK and TrkA/B receptors
Source	Synthetic
Activity	PF-06439015 is a novel potent inhibitor of receptor tyrosine kinases, highly effective against crizotinib-resistant ALK mutants, inhibiting wild-type and mutant ALK phosphorylation with IC50 of 0.8 nM and 0.2 nM-24 nM, respectively. It is shown to inhibit kinase activity of ROS1, FER, LTK and TrkB with IC50 values of under 10 nM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2R)-2-(5-(6-amino-5-((1R)-1-(5-fluoro-2-(triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl)propane-1,2-diol.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C.

Product Manual	SDS

Reference	Huang, Q. et al. (2014) J. Med. Chem. 57, 1170. Paul, M.K. and Mukhopadhyay, A.K. (2004) Int. J. Med. Sci. 1, 101. Huang, Q. et al. (2014) J. Med. Chem. 57, 1170.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300286-1	P-355_10 mg	10 mg	$235		Add to Cart
BHB21300286-2	P-355_25 mg	25 mg	$509		Add to Cart
BHB21300286-3	P-355_5 mg	5 mg	$134		Add to Cart
BHB21300286-4	P-355_50 mg	50 mg	$917		Add to Cart

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