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Home / Biochemicals / Small Molecules

Pyrrolopyrimidine 48

SKU : BHB21300276

A Blocker of NaV1.7 and NaV1.5 Channel

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Alomone Labs

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Mfr.No.	P-275, P-275_10 mg, P-275_25 mg, P-275_5 mg, P-275_50 mg
Description	Pyrrolopyrimidine 48 (#P-275) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C23H23N5O.
Pubchem Cid	73755149
Synonyms	Synthetic
Background	Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel developed using structure-activity relationship of the channel. It blocks human NaV1.7 with an IC50 value of 0.11 uM and NaV1.5 channel with an IC50 of 0.16 uM. It exhibits good selectivity over hERG K+ channel1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50 nM - 20 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Molecular Weight	385.46
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NaV1.7, NaV1.5 channels
Activity	Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel with an IC50 value of 0.11 uM. It also blocks NaV1.5 channel with an IC50 of 0.16 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 7-benzyl-4-(1-pyridin-2-ylpiperidin-4-yl)oxypyrrolo(2,3-d)pyrimidine.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	0 Chakka, N. et al. (2012) Bioorg. Med. Chem. Lett. 22, 2052. Chakka, N. et al. (2012) Bioorg. Med. Chem. Lett. 22, 2052.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300276-1	P-275_10 mg	10 mg	$202		Add to Cart
BHB21300276-2	P-275_25 mg	25 mg	$451		Add to Cart
BHB21300276-3	P-275_5 mg	5 mg	$117		Add to Cart
BHB21300276-4	P-275_50 mg	50 mg	$808		Add to Cart

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