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Home / Biochemicals / Small Molecules

QNZ 46

SKU : BHB21300298

A Potent and Selective Antagonist of GluN2C/GluN2D-Containing NMDA Receptors

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Mfr.No.	Q-270, Q-270_10 mg, Q-270_100 mg, Q-270_25 mg, Q-270_5 mg, Q-270_50 mg
Description	QNZ 46 (#Q-270) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C24H17N3O6.
Synonyms	Synthetic
Background	QNZ 46 is a potent and selective antagonist of GluN2C/GluN2D-containing N-methyl-D-aspartate (NMDA) receptors. It inhibits NMDA receptor function in a non-competitive and voltage-independent manner1. The compound demonstrates IC50 value of 3.9 and 7.1 uM for NR2D and NR2C containing receptors respectively and 182 and over 193 uM for NR2A and NR2B-containing receptors1.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and physiological functions such as, synaptic plasticity, learning and memory formation, addiction and stroke, and are important components in glutamate excitotoxicity. NMDA receptors are also involved in many neurodegenerative conditions including Alzheimer's disease2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-50 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	1237744-13-6
Molecular Weight	443.41
Solubility	Soluble in DMSO up to 10 mM with gentle warming. Centrifuge all products before handling (10000 x g 5 min).
Target	NMDA receptors
Activity	QNZ-46 is a potent, noncompetitive NMDA receptor antagonist, exhibiting significant selectivity for NR2D and NR2C-containing receptors (IC50 = 3 uM and 6 uM, respectively) over NR2A and NR2B-containing receptors (IC50 = 229 uM and >300 uM, respectively)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(6-methoxy-2-((E)-2-(3-nitrophenyl)ethenyl)-4-oxoquinazolin-3-yl)benzoic acid.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Hansen, K.B. and Traynelis, S.F. (2011) J. Neurosci. 31, 3650. Black, S.A. et al. (2014) Front. Cell Dev. Biol. 2, 45.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300298-1	Q-270_10 mg	10 mg	$117		Add to Cart
BHB21300298-2	Q-270_100 mg	100 mg	$611		Add to Cart
BHB21300298-3	Q-270_25 mg	25 mg	$235		Add to Cart
BHB21300298-4	Q-270_5 mg	5 mg	$85		Add to Cart
BHB21300298-5	Q-270_50 mg	50 mg	$383		Add to Cart

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