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Home / Biochemicals / Small Molecules

QO-40

SKU : BHB21300297

An Opener of KCNQ Channels

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Alomone Labs

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Mfr.No.	Q-265, Q-265_10 mg, Q-265_25 mg, Q-265_5 mg
Description	QO-40 (#Q-265) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H11ClF3N3O.
Background	QO-40 potently enhances KCNQ channels. It has the ability to decrease the firing of overactive neurons. In medicine, this compound is being used for the treatment of epilepsy and neuropathic pain. In a study conducted on Chinese hamster ovary cells, QO-40 managed to shift the half-maximal activation voltage in the hyperpolarizing direction in a concentration-dependent manner1. QO-40 demonstrates EC50 value of approximately 7 uM on cloned channels and on native M-currents expressed in dorsal root ganglia neurons1.The voltage-gated M-type potassium channels of the KV7 family encoded by the KCNQ gene family, plays an important role in controlling neuronal excitability. KCNQ gene family seems to affect migraine and neuropathic pain. Several recent studies have shown that genetic mutations in KCNQ channel can lead to neonatal epilepsy in humans and mice.KCNQ channels are expressed in the sensory system including the trigeminal ganglion neurons and dorsal root ganglion2,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	1259536-70-3
Molecular Weight	377.8
Solubility	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCNQ channels
Source	Synthetic
Activity	QO-40 is a KCNQ channel opener with EC50 of ~7 uM on cloned channels and on native M-current in DRG neurons1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-(chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-7(4H)-one.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Jia, C. et al. (2011) Pharmacology 87, 297. Zhang. F. et al. (2013) Br. J. Pharmacol. 168, 1030. Blom, S.M. et al. (2014) PLoS One 9, e100209. Jia, C. et al. (2011) Pharmacology 87, 297.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300297-1	Q-265_10 mg	10 mg	$272		Add to Cart
BHB21300297-2	Q-265_25 mg	25 mg	$603		Add to Cart
BHB21300297-3	Q-265_5 mg	5 mg	$151		Add to Cart

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