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Home / Biochemicals / Small Molecules

QX-222 chloride

SKU : BHB21300296

A Blocker of NaV Channels

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Alomone Labs

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Mfr.No.	Q-200, Q-200_10 mg, Q-200_25 mg, Q-200_50 mg
Description	QX-222 chloride (#Q-200) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C13H21N2OCl.
Background	QX-222 is a quarternary derivative of the local anesthetic Lidocaine. It was shown to block NaV currents and channels in a use-dependent manner.1 The blocking mechanism involves an intracellular binding site, but some NaV channels facilitate the passage of QX-222 via the open channel.2 In addition it was shown to inhibit nicotinic ACh receptor channels.3
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-10 mM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	21236-55-5
Molecular Weight	256.77 (as net anhydrous)
Solubility	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Various NaV Na+ channels
Source	Synthetic
Activity	QX-222 chloride blocks NaV currents1 and also inhibits nicotinic ACh receptor channels2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-((2,6-Dimethylphenyl)amino)-N,N,N-trimethyl-2-oxoetha niminium chloride.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to two weeks at 4°C or six months at -20°C. Protect from light. Hygroscopic.

Product Manual	SDS

Reference	Gintant G. A. and Hoffman B. F. (1984) Pflugers Arch. 400, 121. Tsang, S. Y. et al. (2005) Mol. Pharmacol. 67, 424. Neher E. and Steinbach J. H. (1978) J. Physiol. 277, 153. Gintant, G.A. and Hoffman, B.F. (1984) Plufgers Arch. 400, 121. Neher, E. and Steinbach, J.H. (1978) J. Physiol. 277, 153.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300296-1	Q-200_10 mg	10 mg	$75		Add to Cart
BHB21300296-2	Q-200_25 mg	25 mg	$129		Add to Cart
BHB21300296-3	Q-200_50 mg	50 mg	$223		Add to Cart

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