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Home / Biochemicals / Small Molecules

QX-314 bromide

SKU : BHB21300293

A Local Anesthetic Blocker of Some NaV Channels

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Mfr.No.	Q-100, Q-100_1 g, Q-100_100 mg, Q-100_2.5 g, Q-100_500 mg
Description	QX-314 bromide (#Q-100) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H27N2OBr.
Synonyms	Synthetic
Background	This local anesthetic is a blocker of voltage-dependent Na+ channels. QX-314 blocks all NaV channels once exposed to the intracellular face of the channel protein. However, this compound can penetrate the cell interior once applied outside the cell. Via certain types of NaV channels, it can permeate and exert blocking activity via TTX-sensitive channels.1 Intracellular recordings from inferior olivary neurons in brain stem slice preparations demonstrated that the Na+-dependent action potential was completely blocked for approximately five minutes after impalement with a microelectrode containing 50 mM QX-314, whereas the low-threshold Ca2+ spike was still generated.2 QX-314 is widely used to block NaV channels and used as a tool in neurophysiological recordings.2-5
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-50 mM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	21306-56-9
Molecular Weight	343.3
Solubility	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Various NaV Na+ channels
Activity	QX-314 bromide is an intracellular blocker of NaV channels1-4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium bromide.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to two weeks at 4°C or six months at -20°C. Protect from light. Hygroscopic.

Product Manual	SDS

Reference	Sunami, A. et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 2326. Llinas, R. and Yarom, Y. (1981) J. Physiol. 315, 549. Congar, P. et al. (1995) J. Neurophysiol. 73, 421. Li, D.P. et al. (2005) J. Neurophysiol. 93, 393. Koike-Tani, M. (2005) J. Neurosci. 25, 199. Llinas, R. and Yarom, Y. (1981) J. Physiol. 315, 549. Congar, P. et al. (1995) J. Neurophysiol. 73, 421. Li, D.P. et al. (2005) J. Neurophysiol. 93, 393. Koike-Tani, M. (2005) J. Neurosci. 25, 199.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300293-1	Q-100_1 g	1 g	$569		Add to Cart
BHB21300293-2	Q-100_100 mg	100 mg	$81		Add to Cart
BHB21300293-3	Q-100_2.5 g	2.5 g	$1141		Add to Cart
BHB21300293-4	Q-100_500 mg	500 mg	$317		Add to Cart

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