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Home / Biochemicals / Small Molecules

QX-314 chloride

SKU : BHB21300294

A Local Anesthetic Blocker of NaV Channels

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Alomone Labs

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Mfr.No.	Q-150, Q-150_1 g, Q-150_100 mg, Q-150_50 mg, Q-150_500 mg
Description	QX-314 chloride (#Q-150) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H27N2OCl.
Synonyms	Synthetic
Background	This local anesthetic is a blocker of voltage-dependent Na+ channels. QX-314 blocks all NaV channels once exposed to the intracellular face of the channel protein. However, this compound can penetrate the cell interior once applied outside the cell. Via certain types of NaV channels, it can permeate and exert blocking activity via TTX-sensitive channels.1 Intracellular recordings from inferior olivary neurons in brain stem slice preparations demonstrated that Na+-dependent action potentials were completely blocked for approximately five minutes after impalement with a microelectrode containing 50 mM QX-314, whereas the low-threshold Ca2+ spike was still generated.2 QX-314 is widely used to block NaV channels and used as a tool in neurophysiological recordings.2-5
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-50 mM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Cas Number	########
Molecular Weight	298.85
Solubility	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Various NaV Na+ channels
Activity	QX-314 chloride is an intracellular blocker of NaV channels1-4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium chloride.

Purity	>99% (HPLC)
Form	Lyophilized Powder
Storage	Storage of solutions: Up to two weeks at 4°C or six months at -20°C. Protect from light. Hygroscopic.

Product Manual	SDS

Reference	Sunami, A. et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 2326. Llinas, R. and Yarom, Y. (1981) J. Physiol. 315, 549. Congar, P. et al. (1995) J. Neurophysiol. 73, 421. Li, D.P. et al. (2005) J. Neurophysiol. 93, 393. Koike-Tani, M. (2005) J. Neurosci. 25, 199. Llinas, R. and Yarom, Y. (1981) J. Physiol. 315, 549. Congar, P. et al. (1995) J. Neurophysiol. 73, 421. Li, D.P. et al. (2005) J. Neurophysiol. 93, 393. Koike-Tani, M. (2005) J. Neurosci. 25, 199.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300294-1	Q-150_1 g	1 g	$798		Add to Cart
BHB21300294-2	Q-150_100 mg	100 mg	$211		Add to Cart
BHB21300294-3	Q-150_50 mg	50 mg	$147		Add to Cart
BHB21300294-4	Q-150_500 mg	500 mg	$506		Add to Cart

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