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Home / Biochemicals / Small Molecules

Resiniferatoxin

SKU : BHB21300314

A Potent and Selective Activator of TRPV1 Channel

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Mfr.No.	R-400, R-400_0.5 mg, R-400_50 mcg
Description	Resiniferatoxin (#R-400) is a highly pure, natural, and biologically active compound.
Molecular Formula	C37H40O9.
Synonyms	Natural
Background	Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons.2Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensitization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.1
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	20 nM - 1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	57444-62-9
Molecular Weight	628.72
Solubility	Methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1 channels
Activity	Resiniferatoxin is a potent and selective activator of the TRPV1 (Vanilloid/Capsaicin receptor 1) channel1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: 4-Hydroxy-3-methoxy-((2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)- 3a,3b,6,6a,9a,10,11,11aoctahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9 b-epoxyazuleno(5,4-e)-1,3-benzodioxol-5-yl)benzeneaceta.

Purity	95-98% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to two week at 4°C or six months at -20°C.

Product Manual	SDS

Reference	0 Szallasi, A. and Blumberg, P.M. (1989) Neuroscience 30, 515. Raisinghani, M. et al. (2005) J. Physiol. 567, 771. Szallasi, A. and Blumberg, P.M. (1989) Neuroscience 30, 515.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300314-1	R-400_0.5 mg	0.5 mg	$1728		Add to Cart
BHB21300314-2	R-400_50 mcg	50 mcg	$358		Add to Cart
BHB21300314-3	R-400_0.5 mg	5x0.5 mg	$6910		Add to Cart

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