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Home / Biochemicals / Small Molecules

RJR 2403 oxalate

SKU : BHB21300302

An Agonist of alpha4/beta2 nAChRs

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Mfr.No.	R-115, R-115_10 mg, R-115_25 mg, R-115_5 mg, R-115_50 mg
Description	RJR 2403 oxalate (#R-115) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C12H16N2O4.
Synonyms	Synthetic
Background	Neuronal nAChRs are a larger family of ligand-gated ion channels widely expressed in both the central and the peripheral nervous systems. At least 12 different subunits of nAChRs, including alpha2-alpha10, beta2-beta4, have been identified so far and these subunits form many different sub- types of nAChRs with pentameric structures consisting of homomers or heteromers1. It has been shown that nAChRs are involved in a variety of physiological functions including learning, reinforcement, development, aging and nociception2.RJR-2403 ((E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine or metanicotine) is a potent and effective activator of human alpha4/beta2 receptors with a significant selectivity for this receptor subtype (EC50 value = 16 uM)3. RJR-2403 exhibits potency and selectivity for CNS nAChRs thought to play a role in various CNS disorders3. Functional studies show that RJR-2403 is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 nM for RJR-2403 and EC50 = 591 nM for nicotine)4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	220662-95-3
Molecular Weight	252.3
Solubility	Water. Centrifuge all product preparations before use (10000 x 1 min).
Target	alpha4/beta2 nAChRs
Activity	RJR 2403 oxalate activates alpha4/beta2 nAChR EC50 ~ 16 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Changeux, J.P. and Edelstein, S.J. (1998) Neuron 21, 959. Cordero-Erausquin, M. et al. (2000) Trends Pharmacol. Sci. 21, 211. Papke, R.L. et al. (2000) J. Neurochem. 75, 204. Luetje, C.W. and Patrick, J. (1991) J. Neurosci. 11, 837. Papke, R.L. et al. (2000) J. Neurochem. 75, 204.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300302-1	R-115_10 mg	10 mg	$129		Add to Cart
BHB21300302-2	R-115_25 mg	25 mg	$280		Add to Cart
BHB21300302-3	R-115_5 mg	5 mg	$91		Add to Cart
BHB21300302-4	R-115_50 mg	50 mg	$522		Add to Cart

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