JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

RQ 00203078

SKU : BHB21300307

A Potent and Selective Blocker of TRPM8 Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	R-170, R-170_10 mg, R-170_100 mg, R-170_25 mg, R-170_5 mg, R-170_50 mg
Description	RQ 00203078 (#R-170) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C21H13ClF6N2O5S.
Background	RQ 00203078 is a synthetic compound that acts as a potent and highly selective TRPM8 channel blocker with IC50 values of 8.3 nM and 5.8 nM for human and rat TRPM8 respectively. The compound shows very little inhibitory action against TRPV1, TRPA1, TRPV4 and TRPM2 channel. It is orally available and may be a useful tool for assessing the potential therapeutic use of TRPM81,2.TRPM8 is a Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8-28°C and by chemical agonists such as menthol and icilin. The channel is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons. TRPM8 gene is up-regulated in prostate cancer and other malignancies1,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	1254205-52-1
Molecular Weight	554.84
Solubility	Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	TRPM8 channel
Source	Synthetic
Activity	RQ 00203078 is a potent and selective TRPM8 antagonist, shown to inhibit menthol-evoked human and rat TRPM8-mediated calcium influx with IC50 of 8.3 nM and 5.8 nM, respectively, while being highly selective over hTRPV4, h/rTRPV1, h/rTRPA1 and TRPM21,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)-((4-(trifluoromethoxy)phenyl)methyl)sulfamoyl)benzoic acid.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Ohmi, M. et al. (2014) Bioorg. Med. Chem. Lett. 24, 5364. Okamoto, Y. et al. (2012) Int. J. Oncol. 40, 1431. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737. Ohmi, M. et al. (2014) Bioorg. Med. Chem. Lett. 24, 5364. Okamoto, Y. et al. (2012) Int. J. Oncol. 40, 1431.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300307-1	R-170_10 mg	10 mg	$117		Add to Cart
BHB21300307-2	R-170_100 mg	100 mg	$649		Add to Cart
BHB21300307-3	R-170_25 mg	25 mg	$254		Add to Cart
BHB21300307-4	R-170_5 mg	5 mg	$66		Add to Cart
BHB21300307-5	R-170_50 mg	50 mg	$406		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.