JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

SDZ 205-557 hydrochloride

SKU : BHB21300319

An Antagonist of 5-HT3 Channels and 5-HT4 Receptors

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	S-145, S-145_10 mg, S-145_25 mg, S-145_5 mg, S-145_50 mg
Description	SDZ 205-557 hydrochloride (#S-145) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C14H22Cl2N2O3.
Background	SDZ 205-557 is a potent 5-HT3 and 5-HT4 receptor antagonist with a greater affinity for 5-HT4 receptor with a Ki value of 10.6 nM3. It lacks affinity for other 5-HT receptors. SDZ 205-557 is thus suggested to be used as a useful ligand to characterize and define the 5HT-4 receptor. SDZ 205-557 has the ability to cross the blood brain barrier and has a short duration of action that may complicate its use in vivo1,3.5-HT3 and 5HT4 are members of the serotonin-gated and G protein coupled receptor superfamily respectively. 5-HT3 receptors are expressed throughout the central and peripheral nervous systems. High levels of 5-HT4 receptors can be found in the olfactory system, striatum, hippocampus, and substantia nigra2,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	137196-67-9
Molecular Weight	337.2
Solubility	65 mg/ml in H2O. 100mg/ml in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3, 5HT4 receptors
Source	Synthetic
Activity	SDZ 205-557 hydrochloride is a 5-HT3 and 5-HT4 receptor antagonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate;hydrochloride.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Eglen, R.M. et al. (1993) Br. J. Pharmacol. 108, 376. Fayyaz, M. and Lackner, J.M. (2008) Ther. Clin. Risk Manag. 4, 41. McMahon, L.R. and Cunningham, K.A. (1999) J. Pharmacol. Exp. Ther. 291, 300. Eglen, R.M. et al. (1993) Br. J. Pharmacol. 108, 376.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300319-1	S-145_10 mg	10 mg	$151		Add to Cart
BHB21300319-2	S-145_25 mg	25 mg	$337		Add to Cart
BHB21300319-3	S-145_5 mg	5 mg	$117		Add to Cart
BHB21300319-4	S-145_50 mg	50 mg	$611		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.