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Home / Biochemicals / Small Molecules

SJM-3

SKU : BHB21300329

A Positive Allosteric Modulator of GABA(A) Receptors

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Mfr.No.	S-215, S-215_10 mg, S-215_25 mg, S-215_5 mg, S-215_50 mg
Description	SJM-3 (#S-215) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H15FN4OS.
Background	SJM-3 is a positive allosteric modulator of gamma-aminobutyric acid type A (GABA(A)) receptors. It potentiates GABA(A) receptor currents by binding at the diazepam binding site in the transmembrane domain. SJM-3 was also shown to act as an antagonist at the alpha+/gamma? site of the receptor1.GABA(A) receptors belong to the cys-loop pentameric ligand-gated ion channel family. These receptors are major inhibitory neurotransmitter receptors in the brain and in the mammalian central nervous system and are responsible for mediating GABA action. They are composed of five homologous subunits that are arranged around a central chloride-selective pore. GABA(A) receptors are important targets for many clinical drugs1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Soluble in DMSO. Centrifuge before handling (10000 x g, 5 min).
Cas Number	1234977-97-9
Molecular Weight	354.4
Solubility	Soluble in DMSO. Centrifuge before handling (10000 x g, 5 min).
Target	GABA(A) receptors
Source	Synthetic
Activity	SJM-3 is a novel positive allosteric modulator of GABA(A) receptors at the benzodiazepine modulatory site (pKi = 6.7), strongly potentiating GABA currents at 30 uM via the binding site for diazepam in the transmembrane domain, while acting as an antagonist at the alpha+/gamma? site1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-(2-pyrazin-2-yl-1,3-thiazol-4-yl)methanone.

Purity	>97%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C.

Product Manual	SDS

Reference	Middendorp, S.J. et al. (2015) Neuropharmacology 95, 459. Pomara, N. et al. (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry 56, 35. Middendorp, S.J. et al. (2015) Neuropharmacology 95, 459.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300329-1	S-215_10 mg	10 mg	$287		Add to Cart
BHB21300329-2	S-215_25 mg	25 mg	$577		Add to Cart
BHB21300329-3	S-215_5 mg	5 mg	$168		Add to Cart
BHB21300329-4	S-215_50 mg	50 mg	$917		Add to Cart

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