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Home / Biochemicals / Small Molecules

SKF 96365 hydrochloride

SKU : BHB21300323

A Blocker of CaV3 and TRPC channels and STIM1

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Alomone Labs

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Mfr.No.	S-175, S-175_10 mg, S-175_25 mg, S-175_5 mg, S-175_50 mg
Description	SKF 96365 hydrochloride (#S-175) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C22H27ClN2O3.
Background	SKF 96365 hydrochloride is a synthetic blocker of CaV3 (T-type) voltage gated calcium channels and of TRPC channels. In addition, it has a blocking effect on potassium channels. SKF also inhibits the calcium sensor STIM1 which enables Store-operated Ca2+ entry (SOCE). SKF has an effective concentration of 1-100 uM and an IC50 of 560 nM for CaV3.1 channel. SKF is used to identify CaV3 and TRPC channels in many cell types. In an experiment examining the effect of SKF on CaV3 conductivity, perfusion of 1 uM of SKF reversibly inhibited 86.3±0.1% of CaV3.1 currents generated in HEK293 cells. Maximum inhibition was reached within 6-7 minutes. Application of larger concentrations of SKF completely abolished CaV3.1 channel currents. SKF blocks the CaV3.1 channel in a tonic manner indicating it interacts with the channel regardless of its functional state, unlike other CaV channel blockers. In the same experiment SKF also abolished calcium currents in other types of CaV channels such as P/Q-type and N-type.Blockade of these channels was only partially reversible due to possible irreversible binding of or longer washing time required. In addition, SKF blocks L-type calcium channels but in a much slower manner than other calcium channels.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	100 mM in H2O. Centrifuge all product preparations before use (10 000 x g for 1 min).
Cas Number	130495-35-1
Molecular Weight	402.9
Solubility	100 mM in H2O. Centrifuge all product preparations before use (10 000 x g for 1 min).
Target	CaV3 channels, TRPC, STIM1
Source	Synthetic
Activity	SKF 96365 is an Inhibitor of TRPC channels and inhibitor of T-type calcium channels with an IC50 560 nM for CaV3.1 channels1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)imidazole;hydrochloride.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Singh, A. et al. (2010) Brit. J. Pharmacol. 160, 1464. Singh, A. et al. (2010) Brit. J. Pharmacol. 160, 1464.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300323-1	S-175_10 mg	10 mg	$132		Add to Cart
BHB21300323-2	S-175_25 mg	25 mg	$297		Add to Cart
BHB21300323-3	S-175_5 mg	5 mg	$92		Add to Cart
BHB21300323-4	S-175_50 mg	50 mg	$537		Add to Cart

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