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Home / Biochemicals / Small Molecules

SR 48527

SKU : BHB21300330

A Potent and Selective Antagonist of Neurotensin Receptor 1

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Mfr.No.	S-225, S-225_10 mg, S-225_25 mg, S-225_5 mg, S-225_50 mg
Description	SR 48527 (#S-225) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C29H29ClN4O5.
Synonyms	Synthetic
Background	SR 48527 is a potent and selective antagonist of neurotensin receptor 1 (NTR1/NTS1). It is an analog of SR 48692 and inhibits neurotensin-stimulated IP production with a Ki value of 24 nM1,2.The two neurotensin receptors, NTR1 and NTR2, belong to the family of G-protein-coupled receptors1,2. The receptors are expressed in the brain and gastrointestinal tract where they play a role in pain transmission and intestinal motility.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	156579-04-3
Molecular Weight	549
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	Neurotensin Receptor 1
Activity	SR 48527, an analog of SR 48692, is a potent and selective antagonist of NTS1 receptors, shown to inhibit neurotensin-stimulated IP production with Ki of 24 nM1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2S)-2-((1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl)amino)-2-cyclohexylacetic acid.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Labbe-Jullie, C. et al. (1994) J. Pharmacol. Exp. Ther. 271, 267. Labbe-Jullie, C. et al. (1998) J. Biol. Chem. 273, 16351.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300330-1	S-225_10 mg	10 mg	$235		Add to Cart
BHB21300330-2	S-225_25 mg	25 mg	$469		Add to Cart
BHB21300330-3	S-225_5 mg	5 mg	$134		Add to Cart
BHB21300330-4	S-225_50 mg	50 mg	$747		Add to Cart

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