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Home / Biochemicals / Small Molecules

SR 57227A

SKU : BHB21300320

A Potent and Selective Agonist of 5-HT3 Receptors

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Mfr.No.	S-155, S-155_10 mg, S-155_25 mg, S-155_5 mg, S-155_50 mg
Description	SR 57227A (#S-155) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H15Cl2N3.
Synonyms	Synthetic
Background	SR 57227A is a compound with high affinity and selectivity for activating 5-HT3 receptors. It acts as an agonist for peripheral and central 5-HT3 receptors, both in vitro and in vivo, with IC50 values between 2.8 and 250 nM with no affinity for other subtypes of 5-HT.SD 57227A has the ability to cross the blood brain barrier, unlike many 5-HT3 receptors. Thus, SR 57227A can be used as a useful tool for characterizing the neuropharmacological effects produced by the stimulation of 5-HT3 receptors1.Some findings show that administration of SR 57227A can acutely induce and trigger movements and motor response in the hind limbs of adult paraplegic mice2.Additional findings indicate that SR 57227A exhibits antidepressant-like activity in rodent and decrease isolation induced aggressive behavior3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	77145-61-0
Molecular Weight	248.15
Solubility	50 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Serotonin-gated channels
Activity	SR 57227A is a high affinity, selective 5-HT3 receptor agonist, active in vivo and CNS penetrant1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride.

Purity	>96%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Bachy, A. et al. (1993) Eur. J. Pharmacol. 237, 299. Guertin, P.A. and Steuer, I. (2005) J. Neurophysiol. 94, 3397. Poncelet, M. et al. (1995) J. Neural Transm. Gen. Sect. 102, 83. Bachy, A. et al. (1993) Eur. J. Pharmacol. 237, 299.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300320-1	S-155_10 mg	10 mg	$117		Add to Cart
BHB21300320-2	S-155_25 mg	25 mg	$262		Add to Cart
BHB21300320-3	S-155_5 mg	5 mg	$85		Add to Cart
BHB21300320-4	S-155_50 mg	50 mg	$476		Add to Cart

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