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Home / Biochemicals / Small Molecules

Talampanel

SKU : BHB21300343

A Potent Non-Competitive Antagonist of AMPA/Kainate Receptors

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Mfr.No.	T-185, T-185_10 mg, T-185_25 mg, T-185_5 mg, T-185_50 mg
Description	Talampanel (#T-185) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H19N3O3.
Synonyms	Synthetic
Background	Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to a number of different receptors such as AMPA, Kainate and NMDA that relay its excitatory activity.Talampanel (Ampanel, Kinampa, LY 300164, GYKI 53773) is a potent non-competitive AMPA and Kainate antagonist. It has an effective concentration of 10-300 uM. Talampanel was examined in several animal models; sub protective doses of Talampanel potentiate the anticonvulsant effect of other anticonvulsant drugs such as valproate and phenytoin. In addition, it shows neuroprotective properties by enabling the survival of hippocampal neurons after carotid artery occlusion. Repeated administrations of Talampanel in rats undergoing middle cerebral artery occlusion (MCAO) caused an improvement in rotarod and beam walking and reduced the number of MCAO induced rotations compared to rats receiving placebo treatment. In humans, Talampanel is administered orally and is well absorbed. It reaches peak concentration after 2 hours with a half-life of 4 hours. In humans, administering valproate with talampanel does not affect talampanel and N-acetyl-talampanel kinetics. Talampanel is used for the treatment of epilepsy and is well tolerated in adults with refractory complex partial seizures. Its main adverse effects are dizziness and ataxia.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-300 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
Cas Number	161832-65-1
Molecular Weight	337.37
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
Target	AMPA/Kainate receptors
Activity	Talampanel is a potent non-competitive AMPA/kainate receptor antagonist. It potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures and is orally active1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-((8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-(1,3)dioxolo(4,5-h)(2,3)benzodiazepin-7-yl)ethanone.

Purity	>97.8%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Howes, J.F. et al. (2007) Neurotherapeutics 4, 126. Czuczwar, S.J. et al. (1998) Eur. J. Pharmacol. 359, 103.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300343-1	T-185_10 mg	10 mg	$117		Add to Cart
BHB21300343-2	T-185_25 mg	25 mg	$272		Add to Cart
BHB21300343-3	T-185_5 mg	5 mg	$66		Add to Cart
BHB21300343-4	T-185_50 mg	50 mg	$527		Add to Cart

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