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Home / Biochemicals / Small Molecules

TCN 213

SKU : BHB21300348

An Antagonist of NMDA Receptors

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Mfr.No.	T-215, T-215_10 mg, T-215_25 mg, T-215_5 mg, T-215_50 mg
Description	TCN 213 (#T-215) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H24N4OS2.
Synonyms	Synthetic
Background	TCN 213 acts as a selective and potent NMDA (methyl-d-aspartate) receptor antagonist. This compound displays a high selectivity for GluN1/GluN2A-containing NMDAR receptors over GluN1GluN1/GluN2B containing NMDAR receptors. The degree of its antagonism is dependent on the concentration of the GluN1-site co-agonist, glycine or d-serine, and is independent of the glutamate concentration1. Relatively high concentrations of TCN 213 are required to achieve substantial block of GluN2A NMDAR-mediated responses.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. NMDAR plays an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 uM - 1 mM.
Reconstitution	Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	556803-08-8
Molecular Weight	376.54
Solubility	Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NMDA receptors
Activity	TCN 213 is a NMDA receptor antagonist, selective for NR2A- over NR2B-containing receptors. Inhibits human recombinant NR1/NR2A with pIC50 of 5.4 in FLIPR/Ca2+ assay1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-((5-(benzylamino)-1,3,4-thiadiazol-2-yl)sulfanyl)-N-(cyclohexylmethyl)acetamide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Edman, S. et al. (2012) Neuropharmacology 63, 441. Black, S.A. et al. (2014) Front. Cell. Dev. Biol. 2, 45. Bettini, E. et al. (2010) J. Pharmacol. Exp. Ther. 335, 636.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300348-1	T-215_10 mg	10 mg	$184		Add to Cart
BHB21300348-2	T-215_25 mg	25 mg	$417		Add to Cart
BHB21300348-3	T-215_5 mg	5 mg	$117		Add to Cart
BHB21300348-4	T-215_50 mg	50 mg	$747		Add to Cart

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