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Home / Biochemicals / Small Molecules

Thapsigargin

SKU : BHB21300356

A Potent and Cell-Permeable Inhibitor of SERCA Pump Ca2+-ATPase/an Intracellular Ca2+ Mobilizer

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Mfr.No.	T-650, T-650_0.65 mg, T-650_1 mg, T-650_10 mg, T-650_5 mg
Description	Thapsigargin (#T-650) is a highly pure, natural and biologically active compound.
Molecular Formula	C34H50O12.
Background	Thapsigargin, derived from the plant genus Thapsia,1-3 is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent which induces rapid Ca2+ release from intracellular stores4 by inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-dependent ATPase pump without inositol phosphate formation.5-7 The thapsigargin induced depletion of Ca2+ stores causes apoptosis in most cell lines.8-10 It has also been shown to cause histamine secretion from rat mast cells,11 and to stimulate arachidonic acid metabolism in macrophages.12 Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in the skin.13 The tumorogenic activity of thapsigargin might be due to its activation of protein kinase B (Akt) which subsequently stimulates MAP kinase signaling via Src and Raf-1.12,13
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50 nM - 1 uM.
Reconstitution	DMSO, ethanol or acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	67526-95-8
Molecular Weight	650.7
Solubility	DMSO, ethanol or acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Target	SERCA
Source	Natural
Activity	Thapsigargin is a highly potent inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPases (SERCAs), inhibiting Ca2+ pumping to intracellular stores at nanomolar concentrations, with IC50 ranging from 0.2 nM to 50 nM in various mammalian cell types.1 Thapsigargin-induced depletion of Ca2+ stores leads to apoptosis in various cell lines.2-4
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6 ,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-( ((2Z)-2-methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutox y)azuleno(4,5-b)furan-7-yl octanoate.

Purity	>99% (HPLC)
Form	Lyophilized Powder
Storage	Storage of solutions: Up to one week at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Treiman, M. et al. (1998) Trends Pharmacol. Sci. 19, 131. Rodriguez-Lopez, A.M. et al. (1999) Cell Physiol. Biochem. 9, 285. Waring, P. and Beaver, J. (1996) Exp. Cell. Res. 227, 264. Wei, H. et al. (1998) J. Neurochem. 70, 2305. Christensen, S.B. et al. (1980) Tetrahedron Lett. 21, 3829. Christensen, S.B. et al. (1982) J. Org. Chem. 47, 649. Rasmussen, U. et al. (1978) Acta Pharm. Suec. 15, 133. Jackson, T.R. et al. (1988) Biochem. J. 253, 81. Sagara, Y. and Inesi, G. (1991) J. Biol. Chem. 266, 13503. Lytton, J. et al. (1991) J. Biol. Chem. 266, 17067. Takemura, H. et al. (1989) J. Biol. Chem. 264, 12266. Patkar, S.A. (1979) Agents Actions 9, 53. Ohuchi, K. et al. (1987) J. Cancer Res. Clin. Oncol. 113, 319. Rodriguez-Lopez, A.M. et al. (1999) Cell Physiol. Biochem. 9, 285. Wei, H. et al. (1998) J. Neurochem. 70, 2305. Waring, P. and Beaver, J. (1996) Exp. Cell. Res. 227, 264. Jackson, T.R. et al. (1988) Biochem. J. 253, 81.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300356-1	T-650_0.65 mg	0.65 mg	$76		Add to Cart
BHB21300356-2	T-650_1 mg	1 mg	$92		Add to Cart
BHB21300356-3	T-650_10 mg	10 mg	$612		Add to Cart
BHB21300356-4	T-650_5 mg	5 mg	$343		Add to Cart

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