JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Tracazolate hydrochloride

SKU : BHB21300350

A Modulator of GABA(A) Receptors

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	T-230, T-230_10 mg, T-230_25 mg, T-230_5 mg, T-230_50 mg
Description	Tracazolate hydrochloride (#T-230) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H25ClN4O2.
Synonyms	Synthetic
Background	Tracazolate hydrochloride, a pyrazolopyridine, is a non-sedative anxiolytic compound that acts as an allosteric modulator of GABA(A) receptors. Tracazolate was shown to potentiate the GABA(A) receptor with an EC50 value of 1.1 uM and inhibit with an IC50 value of 1.2 uM1.In addition to its anxiolytic activity, tracazolate possesses anticonvulsant activity that was shown in behavioral studies. Tracazolate seems to cause less adverse interactions in combination with barbiturates and alcohol and demonstrates a wider separation between sedative and therapeutic doses than the benzodiazepines1,2.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system. They also play an important role in inhibiting cell excitation in the central nervous system, and are considered to be a major target of antiseizure drugs3,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 uM.
Reconstitution	Soluble in 1eq. HCl and in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).
Cas Number	41094-88-6
Molecular Weight	340.85
Solubility	Soluble in 1eq. HCl and in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).
Target	GABA(A) receptors
Activity	Tracazolate is an allosteric modulator of GABA(A) receptors, that was shown to potentiate (EC50 = 1.1-16.7 uM) or inhibit (IC50 = 1.2-4.0 uM) GABA-evoked currents in a subunit combination dependent manner1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: Ethyl-4-(butylamino)-1-ethyl-6-methylpyrazolo(3,4-b)pyridine-5-carboxylate;hydrochloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Thompson, S.A. et al. (2002) Mol. Pharmacol. 61, 861. Zheleznova, N. et al. (2008) Br. J. Pharmacol. 153, 1062. Pomara, N. et al. (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry 56, 35. Iqbal, F. et al. (2011) Bioorg. Med. Chem. Lett. 21, 4252. Thompson, S.A. et al. (2002) Mol. Pharmacol. 61, 861.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300350-1	T-230_10 mg	10 mg	$85		Add to Cart
BHB21300350-2	T-230_25 mg	25 mg	$184		Add to Cart
BHB21300350-3	T-230_5 mg	5 mg	$66		Add to Cart
BHB21300350-4	T-230_50 mg	50 mg	$333		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.