JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Trimethylapigenin

SKU : BHB21300340

A Blocker of KV1.5 and KV11.1 and an Activator of CFTR Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	T-145, T-145_10 mg, T-145_25 mg, T-145_5 mg, T-145_50 mg
Description	Trimethylapigenin (#T-145) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H16O5.
Background	Trimethylapigenin is a natural flavone and a fully methylated derivate of apigenin, present in citrus, kaempferia parviflora, etc. Trimethylapigenin inhibits cardiac potassium currents. This compound blocks KV1.5 current in HEK 293 cell line (IC50 = 6.4 uM), and the ultra-rapid delayed rectify K+ current (IKur) in human atrial myocytes (IC50 = 8.0 uM) by binding to the open channels. In addition, trimethylapigenin decreased transient outward K+ current (Ito) in human atrial myocytes, inhibited acetylcholine-activated K+ current (IC50 = 6.8 uM) in rat atrial myocytes1.It has been demonstrated that trimethylapigenin is effective in modulating bacterial drug resistance, and in alpha-glycosidase inhibition, anti-adipogenesis, anti-carcinoma, anti-inflammation, and chemoprevention. In addition, trimethylapigenin has been found to activate CFTR Cl? channels1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-200 uM.
Reconstitution	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	5631-70-9
Molecular Weight	312.3
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	KV1.5, KV11.1, CFTR channels
Source	Synthetic
Activity	Trimethylapigenin blocks KV1.5 and hERG channels with IC50 ~ 8 and 30 uM respectively. It also activates CFTR channels1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one.

Purity	>96%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Liu, Y. et. al. (2012) Biochem. Pharmacol. 84, 498.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300340-1	T-145_10 mg	10 mg	$272		Add to Cart
BHB21300340-2	T-145_25 mg	25 mg	$627		Add to Cart
BHB21300340-3	T-145_5 mg	5 mg	$184		Add to Cart
BHB21300340-4	T-145_50 mg	50 mg	$1189		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.