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Home / Biochemicals / Small Molecules

Valerenic acid

SKU : BHB21300370

A Positive Allosteric Modulator of the GABAA Receptors

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Mfr.No.	V-140, V-140_1 mg, V-140_10 mg, V-140_25 mg, V-140_5 mg
Description	Valerenic acid (#V-140) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H22O2
Synonyms	Synthetic
Background	Valerenic acid was first isolated in 1957 from the rhizome and roots of valerian (Valeriana offi-cinalis). Valerian is one of the oldest medicinal herbs in folk medicine and has been used for various afflictions like insomnia, anxiety, and pain. Valerenic acid was found to be pharmacologically active monoterpene acting through binding to the GABAA receptor1.Valerenic acid acts as an anti-inflammatory agent by inhibiting the transcription of NF-kappaB, one essential transcription factor controlling the expression of numerous inflammation-related genes. In addition, evidence suggests that Valerenic acid acts as an agonist for 5-HT receptors (serotonin receptors), which are G-coupled receptors that mediates neuronal activity via regulating cyclic adenosine monophosphate (cAMP) levels2.In-vivo studies that conducted on xenograft glioblastoma multiforme (GBM) mice models shown that Valerenic acid induce cell death of GBM cells by inducing AMPK activation. Therefore, Valerenic acid may serve as a potential anti-tumor agent towards GBM patients3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 - 200 uM
Reconstitution	Soluble in Ethanol and DMSO.Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Cas Number	########
Molecular Weight	234.33
Solubility	Soluble in Ethanol and DMSO.Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	GABAA receptor
Activity	Valerenic acid is a positive allosteric modulator of GABAA receptors that displays preference for beta2 or beta3 subunit receptors. Directly activates the receptor and also blocks the channel at high concentrations. Displays an anxiolytic and sedative activity in vivo1-3. Also acts as a partial agonist of 5-HT5A receptors4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2E)-3-((4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl)-2-methyl-2-propenoic acid

Purity	>98% (HPLC)
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Ramharter, J. et al (2012) EurJOC., 10, 2041. Dietz, B.M. et al. (2005) Mol. Brain. Res., 138, 191. Lu, Q. et al. (2020) Int. J. Biol. Sci., 16, 2104. Khom, S. et al. (2007) Neuropharmacol., 53, 178. Benke, D. et al. (2008) Neuropharmacol. 56, 174. Khom, S. et al. (2016) J. Pharmacol. Exp. Ther. 357, 580. Dietz, B.M. et al. (2005) Brain Res. Mol. Brain Res., 138, 191.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300370-1	V-140_1 mg	1 mg	$81		Add to Cart
BHB21300370-2	V-140_10 mg	10 mg	$508		Add to Cart
BHB21300370-3	V-140_25 mg	25 mg	$894		Add to Cart
BHB21300370-4	V-140_5 mg	5 mg	$318		Add to Cart

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