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Home / Biochemicals / Small Molecules

Veratridine

SKU : BHB21300365

An Enhancer of NaV Channel Activity and an Inducer of Transmitter Release

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Mfr.No.	V-110, V-110_10 mg, V-110_25 mg, V-110_5 mg, V-110_50 mg
Description	Veratridine (#V-110) is a highly pure, natural, and biologically active compound.
Molecular Formula	C36H51NO11.
Background	Veratridine is an alkaloid extracted from the Veratrum officinale plant. It is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability of NaV1.4 channels expressed in a mammalian cell line3. Veratridine affects differentially the TTX-sensitive and TTX-resistant components of NaV currents in rat DRG neurons. Although veratridine inhibits both components at the peak current, it is much more effective in increasing the persistent component (channel opening) of the TTX-sensitive current4. Veratridine is widely used in different excitable preparations to induce NaV channel dependent transmitter release (see for example reference #5).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-200 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	71-62-5
Molecular Weight	673.8
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Various NaV Na+ channels
Source	Natural
Activity	Veratridine is an alkaloid which is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4alpha,9-Epoxy-3beta-veratroyloxy-5beta-cevan-4beta,12,14,16beta,17,20-hexaol.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Catterall, W.A. (1975) J. Biol. Chem. 250, 4053. Blaustein, M.P. (1975) J. Physiol. 247, 617. Wang, G.K. and Wang, S.Y. (2003) J. Physiol. 548, 667. Farrag, K.J. et al. (2007) Pflugers Arch. Eur. J. Physiol. 455, 929. Westphalen, R.I. et al. (2011) Neuropharmacology 61, 699. Catterall, W.A. (1975) J. Biol. Chem. 250, 4053. Blaustein, M.P. (1975) J. Physiol. 247, 617. Wang, G.K. and Wang, S.Y. (2003) J. Physiol. 548, 667.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300365-1	V-110_10 mg	10 mg	$103		Add to Cart
BHB21300365-2	V-110_25 mg	25 mg	$211		Add to Cart
BHB21300365-3	V-110_5 mg	5 mg	$81		Add to Cart
BHB21300365-4	V-110_50 mg	50 mg	$358		Add to Cart

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