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Home / Biochemicals / Small Molecules

VU591

SKU : BHB21300367

A Blocker of Kir1.1 Channel

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Alomone Labs

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Mfr.No.	V-125, V-125_10 mg, V-125_25 mg, V-125_5 mg
Description	VU591 (#V-125) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H12N6O5.
Background	VU591 is a potent and selective blocker of renal outer medullary potassium channel, ROMK (Kir1.1). Kir1.1 channel is a putative drug target for a novel class of loop diuretic drugs that hold the ability to lower pressure and blood volume without causing hypokalemia. VU591 seems to block the intracellular pore of the channel and does so with an IC50 of 300 nM.ROMK channels are expressed in the thick ascending limb of Henle's loop, connecting tubule, and collecting duct segments of the nephron. They mediate K+ secretion into the urinary filtrate. ROMK provides K+ ions in the thick ascending limb that are necessary for NaCl reabsorption by the Na+-K+-2Cl? cotransporter and loop diuretic target. In the connecting tubule and collecting duct, ROMK constitutes a key pathway for K+ secretion.Evidence shows that ROMK antagonists could serve as potent diuretic drugs by inhibiting Na+ reabsorption in the thick ascending limb of Henle's loop and minimizing urinary K+ ions loss in the collecting duct. Thus, administration of VU591, a direct diuretic, can avoid hypokalemia, a side effect caused from treatment of conventional loop and thiazide diuretics in cases of hypertension and congestive heart failure.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-50 uM.
Reconstitution	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	1222810-74-3
Molecular Weight	368.3
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Kir1.1 channel
Source	Synthetic
Activity	VU591 is a Kir1.1 channel blocker1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6-nitro-2-((6-nitro-1H-benzimidazol-2-yl)methoxymethyl)-1H-benzimidazole.

Purity	>=99%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Bhave, G. et al. (2011) Mol. Pharmacol. 79, 42.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300367-1	V-125_10 mg	10 mg	$134		Add to Cart
BHB21300367-2	V-125_25 mg	25 mg	$297		Add to Cart
BHB21300367-3	V-125_5 mg	5 mg	$85		Add to Cart

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